PMID- 26664025
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151215
LR  - 20201001
IS  - 0973-1296 (Print)
IS  - 0976-4062 (Electronic)
IS  - 0973-1296 (Linking)
VI  - 11
IP  - Suppl 2
DP  - 2015 Oct
TI  - Xanthii Fructus inhibits allergic response in the ovalbumin-sensitized mouse 
      allergic rhinitis model.
PG  - S352-61
LID - 10.4103/0973-1296.166058 [doi]
AB  - BACKGROUND: Xanthii Fructus (XF) is widely used in traditional anti-bacterial and 
      anti-inflammatory Asian medicine. Allergic rhinitis is a common inflammatory 
      disease characterized by markedly increased levels of anti-inflammatory factors 
      and the recruitment of inflammatory cells into the nasal mucosa. We investigated 
      the effects of XF in the allergen-induced rhinitis model. MATERIALS AND METHODS: 
      Following ovalbumin (OVA)/alum intraperitoneal injection on days 0, 7 and 14, the 
      BALB/c mice (albino, laboratory-bred strain of the house mice) were challenged 
      intranasally with OVA for 10 days a week after the last sensitization. The number 
      of sneezes was recorded for 10 days; additionally, the levels of cytokines, 
      histamine, immunoglobulin E (IgE) and OVA-specific serum IgE were estimated. 
      Eosinophil infiltration, thickness of nasal mucosa and expression of caspase-1 
      were determined by immunohistochemistry. We also evaluated the effect of XF on 
      the phosphorylation of nuclear factor kappa-B (NF-kappaB) and inhibitor of nuclear 
      factor kappa B-alpha (IkappaB-alpha) in human mast cell-1 (HMC-1), by Western blotting. 
      RESULTS: The administration of XF significantly decreased sneezing and the serum 
      levels of histamine, IgE, OVA-specific IgE, and cytokines such as tumor necrosis 
      factor-alpha (TNF-alpha), interleukine-1 beta (IL-1beta), IL-5, IL-6, monocyte 
      chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2). 
      XF inhibited the changes in thickness of the nasal septum, influx of eosinophils 
      and expression of capase-1. In addition, XF inhibited the phosphorylation of 
      IkappaB-alpha and NF-kappaB in phorbol-myristate-acetate plus calcium ionophore A23187 
      (A23187) stimulated HMC-1. CONCLUSION: This study suggests that XF acts a potent 
      anti-allergic drug which alleviates the allergic responses in 
      ovalbumin-sensitized mouse allergic rhinitis model.
FAU - Gwak, Nam-Gil
AU  - Gwak NG
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Kim, Eun-Young
AU  - Kim EY
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Lee, Bina
AU  - Lee B
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Kim, Jae-Hyun
AU  - Kim JH
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Im, Yong-Seok
AU  - Im YS
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Lee, Ka-Yeon
AU  - Lee KY
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Jun-Kum, Chang
AU  - Jun-Kum C
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Kim, Ho-Seok
AU  - Kim HS
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Cho, Hyun-Joo
AU  - Cho HJ
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Jung, Hyuk-Sang
AU  - Jung HS
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
FAU - Sohn, Youngjoo
AU  - Sohn Y
AD  - Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, 
      Kyung Hee University, Seoul, Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacogn Mag
JT  - Pharmacognosy magazine
JID - 101300403
PMC - PMC4653347
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Xanthii Fructus
OT  - histamine
OT  - immunoglobulin E
OT  - nasal symptom
OT  - nuclear factor kappa-B
COIS- Conflict of Interest: None declared.
EDAT- 2015/12/15 06:00
MHDA- 2015/12/15 06:01
PMCR- 2015/10/01
CRDT- 2015/12/15 06:00
PHST- 2015/12/15 06:00 [entrez]
PHST- 2015/12/15 06:00 [pubmed]
PHST- 2015/12/15 06:01 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - PM-11-352 [pii]
AID - 10.4103/0973-1296.166058 [doi]
PST - ppublish
SO  - Pharmacogn Mag. 2015 Oct;11(Suppl 2):S352-61. doi: 10.4103/0973-1296.166058.