PMID- 2666453 OWN - NLM STAT- MEDLINE DCOM- 19890829 LR - 20190824 IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 29 IP - 6 DP - 1989 Jun TI - The monoamine oxidase inhibitor-tyramine interaction. PG - 529-32 AB - Reports of hypertensive reactions from monoamine oxidase inhibitors (MAOI) began to proliferate in the early 1960s. Asatoor did extensive research and found that the combination of an MAOI and a food containing tyramine resulted in the hypertensive interaction ("the cheese reaction"). Because of the risk of intracerebral hemorrhage and death, clinicians were hesitant to use the MAOIs. Although progress on the metabolic effects of MAOIs has been slow, use of clinical information in addition to analysis of bioactive amine content of foods has allowed the formulation of dietary recommendations, which are thought to be useful clinically in the administration of MAOIs. This has resulted in the gradual return to use of these psychotropic compounds. FAU - Brown, C AU - Brown C AD - University of Tennessee, Memphis. FAU - Taniguchi, G AU - Taniguchi G FAU - Yip, K AU - Yip K LA - eng PT - Journal Article PT - Review PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Monoamine Oxidase Inhibitors) RN - X8ZC7V0OX3 (Tyramine) SB - IM MH - Diet MH - Humans MH - Hypertension/*chemically induced/physiopathology MH - Monoamine Oxidase Inhibitors/*adverse effects MH - Tyramine/*adverse effects RF - 20 EDAT- 1989/06/01 00:00 MHDA- 1989/06/01 00:01 CRDT- 1989/06/01 00:00 PHST- 1989/06/01 00:00 [pubmed] PHST- 1989/06/01 00:01 [medline] PHST- 1989/06/01 00:00 [entrez] AID - 10.1002/j.1552-4604.1989.tb03376.x [doi] PST - ppublish SO - J Clin Pharmacol. 1989 Jun;29(6):529-32. doi: 10.1002/j.1552-4604.1989.tb03376.x.