PMID- 26666473
OWN - NLM
STAT- MEDLINE
DCOM- 20161219
LR  - 20170916
IS  - 1440-1592 (Electronic)
IS  - 1323-8930 (Linking)
VI  - 65
IP  - 2
DP  - 2016 Apr
TI  - Natural history of immediate-type hen's egg allergy in Japanese children.
PG  - 153-157
LID - S1323-8930(15)00201-4 [pii]
LID - 10.1016/j.alit.2015.10.005 [doi]
AB  - BACKGROUND: Hen's egg (HE) allergy develops during infancy. We investigated 
      tolerance acquisition in Japanese children allergic to HE aging <6 years. 
      METHODS: In this retrospective study, 226 children born in 2005 with a history of 
      immediate-type HE allergy underwent an oral food challenge (OFC). Tolerance was 
      defined as no reaction to an OFC with half of whole heated HE or accidental HE 
      consumption at home. Participants were divided into three groups based on age at 
      tolerance acquisition: group I (<3 years) (n = 66), group II (3-6 years) 
      (n = 98), and group III (prolonged allergic groups) (n = 62). RESULTS: Tolerance 
      acquisition occurred in 30% (66/226) by 3 years of age, 59% (133/226) by 5 years 
      of age, and 73% (164/226) at 6 years of age. At 3 years, incidences of 
      allergy-related complications (bronchial asthma, p = 0.02; atopic dermatitis, 
      p = 0.04) were higher in the group III than in the group I. Anaphylaxis to any 
      food occurred more frequently in the group III than in the group I (p = 0.03); 
      anaphylaxis to HE was more common in the group III (p = 0.04). Egg white (EW)- 
      and ovomucoid (OM)-specific immunoglobulin E (IgE) levels were higher in the 
      group III than in the group I (p < 0.05). CONCLUSIONS: The group III experienced 
      HE-related anaphylaxis and complications more frequently and exhibited sustained, 
      high EW- and OM-specific IgE levels.
CI  - Copyright (c) 2015 Japanese Society of Allergology. Production and hosting by 
      Elsevier B.V. All rights reserved.
FAU - Ohtani, Kiyotaka
AU  - Ohtani K
AD  - Clinical Research Center for Allergy and Rheumatology, Sagamihara National 
      Hospital, Kanagawa, Japan; Department of Pediatrics, Sagamihara Kyodo Hospital, 
      Kanagawa, Japan.
FAU - Sato, Sakura
AU  - Sato S
AD  - Clinical Research Center for Allergy and Rheumatology, Sagamihara National 
      Hospital, Kanagawa, Japan.
FAU - Syukuya, Akinori
AU  - Syukuya A
AD  - Futaba Kodomo Clinic, Tokyo, Japan.
FAU - Asaumi, Tomoyuki
AU  - Asaumi T
AD  - Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan.
FAU - Ogura, Kiyotake
AU  - Ogura K
AD  - Clinical Research Center for Allergy and Rheumatology, Sagamihara National 
      Hospital, Kanagawa, Japan.
FAU - Koike, Yumi
AU  - Koike Y
AD  - Department of General Medicine, Nagano Children's Hospital, Nagano, Japan.
FAU - Iikura, Katsuhito
AU  - Iikura K
AD  - Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan.
FAU - Yanagida, Noriyuki
AU  - Yanagida N
AD  - Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan.
FAU - Imai, Takanori
AU  - Imai T
AD  - Clinical Research Center for Allergy and Rheumatology, Sagamihara National 
      Hospital, Kanagawa, Japan; Department of Pediatrics, Showa University, Tokyo, 
      Japan.
FAU - Ebisawa, Motohiro
AU  - Ebisawa M
AD  - Clinical Research Center for Allergy and Rheumatology, Sagamihara National 
      Hospital, Kanagawa, Japan. Electronic address: m-ebisawa@sagamihara-hosp.gr.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151128
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - *Chickens
MH  - Child
MH  - Child, Preschool
MH  - Egg Hypersensitivity/*epidemiology/immunology
MH  - Egg White/adverse effects
MH  - Eggs/*adverse effects
MH  - Female
MH  - Humans
MH  - Immune Tolerance
MH  - Immunoglobulin E/blood/immunology
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Japan/epidemiology
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Egg white-specific immunoglobulin E (IgE) antibodies
OT  - Hen's egg
OT  - Oral food challenge
OT  - Ovomucoid-specific IgE
OT  - Tolerance acquisition
EDAT- 2015/12/17 06:00
MHDA- 2016/12/20 06:00
CRDT- 2015/12/16 06:00
PHST- 2015/05/14 00:00 [received]
PHST- 2015/10/09 00:00 [revised]
PHST- 2015/10/14 00:00 [accepted]
PHST- 2015/12/16 06:00 [entrez]
PHST- 2015/12/17 06:00 [pubmed]
PHST- 2016/12/20 06:00 [medline]
AID - S1323-8930(15)00201-4 [pii]
AID - 10.1016/j.alit.2015.10.005 [doi]
PST - ppublish
SO  - Allergol Int. 2016 Apr;65(2):153-157. doi: 10.1016/j.alit.2015.10.005. Epub 2015 
      Nov 28.