PMID- 26667468
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20191210
IS  - 1613-7671 (Electronic)
IS  - 0043-5325 (Linking)
VI  - 127 Suppl 5
DP  - 2015 Dec
TI  - Non-invasive measuring of the acceleration of contraction of the left ventricle 
      with the Doppler echocardiography.
PG  - S288-94
LID - 10.1007/s00508-015-0916-2 [doi]
AB  - BACKGROUND: Echocardiographically measured ejection fraction (EF) of the left 
      ventricle (LV) is the most useful standard of the LV systolic function. Its 
      limitations are poor delineation of the LV endocardium, pronounced regional 
      disorders of contractility, dyssynchrony of the LV and in particular significant 
      mitral regurgitation. The aim of this research is to evaluate the advantage of 
      Doppler indices of left ventricular function such as index of acceleration of 
      contraction of the LV (AccLV) over EF in patients with heart failure. METHODS: We 
      performed a prospective observational study. We included 45 patients with known 
      chronic heart failure and 76 healthy subjects. We performed standard 
      echocardiographic measurements. AccLV was calculated by the following formula: 
      AccLV = Vmax LVOT/dt x EDV [cm/s(2) ml]. Vmax LVOT represents the maximum 
      velocity during ejection in the left ventricular outflow tract (LVOT), dt stands 
      for the interval from the beginning of the LV contraction to the achieved Vmax 
      LVOT, EDV represents end-diastolic volume of the LV. RESULTS: Between patients 
      and healthy subjects we observed statistically significant differences in mean EF 
      values (65.4 +/- 6.7 % vs. 38.6 +/- 18.0 %; p < 0.001) and of AccLV (12.1 +/- 2.88 
      cm/s(2)ml vs. 4.4 +/- 2.1 cm/s(2)ml; p < 0.001). Receiver operating characteristic 
      (ROC) curve showed higher area under the curve values for AccLV in comparison to 
      EF (0.996 vs. 0.897). In the patient group we observed more important correlation 
      between AccLV index and the New York Heart Association (NYHA) functional classes 
      (r = - 0.657; p < 0.001), than between EF and the NYHA classes (r = - 0.539; 
      p < 0.001). CONCLUSIONS: We could distinguish with higher accuracy between 
      healthy subjects and patients with heart failure LV by calculated AccLV in 
      comparison to EF. AccLV values correlated with NYHA functional classes in 
      patients with heart failure better than EF values.
FAU - Krajnc, Igor
AU  - Krajnc I
AD  - Department of Cardiology and Angiology, Division of Internal Medicine, University 
      Medical Centre Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia. 
      hisa.krajnc@amis.net.
FAU - Sinkovic, Andreja
AU  - Sinkovic A
AD  - Department of Intensive and Internal Medicine, Division of Internal Medicine, 
      Faculty of Medicine, University Medical Centre Maribor, University of Maribor, 
      Maribor, Slovenia.
FAU - Naji, Franjo
AU  - Naji F
AD  - Department of Cardiology and Angiology, Division of Internal Medicine, University 
      Medical Centre Maribor, Maribor, Slovenia.
FAU - Krajnc, Ivan
AU  - Krajnc I
AD  - Faculty of Medicine, University of Maribor, Maribor, Slovenia.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20151214
PL  - Austria
TA  - Wien Klin Wochenschr
JT  - Wiener klinische Wochenschrift
JID - 21620870R
SB  - IM
MH  - *Acceleration
MH  - Adult
MH  - Algorithms
MH  - Echocardiography, Doppler/methods
MH  - Heart Failure/complications/*diagnostic imaging/*physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Middle Aged
MH  - *Myocardial Contraction
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/*physiopathology
OTO - NOTNLM
OT  - Acceleration
OT  - Doppler
OT  - Ejection fraction
OT  - Heart failure
OT  - Left ventricle
EDAT- 2015/12/17 06:00
MHDA- 2016/09/27 06:00
CRDT- 2015/12/16 06:00
PHST- 2015/09/16 00:00 [received]
PHST- 2015/11/30 00:00 [accepted]
PHST- 2015/12/16 06:00 [entrez]
PHST- 2015/12/17 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
AID - 10.1007/s00508-015-0916-2 [pii]
AID - 10.1007/s00508-015-0916-2 [doi]
PST - ppublish
SO  - Wien Klin Wochenschr. 2015 Dec;127 Suppl 5:S288-94. doi: 
      10.1007/s00508-015-0916-2. Epub 2015 Dec 14.