PMID- 26668238
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20191210
IS  - 1945-2403 (Electronic)
IS  - 0146-4760 (Linking)
VI  - 40
IP  - 2
DP  - 2016 Mar
TI  - A Retrospective Analysis of Urine Drugs of Abuse Immunoassay True Positive Rates 
      at a National Reference Laboratory.
PG  - 97-107
LID - 10.1093/jat/bkv133 [doi]
AB  - Urine drug screens are commonly performed to identify drug use or monitor 
      adherence to drug therapy. The purpose of this retrospective study was to 
      evaluate the true positive and false positive rates of one of our in-house urine 
      drug screen panels. The urine drugs of abuse panel studied consists of screening 
      by immunoassay then positive immunoassay results were confirmed by mass 
      spectrometry. Reagents from Syva and Microgenics were used for the immunoassay 
      screen. The screen was performed on a Beckman AU5810 random access automated 
      clinical analyzer. The percent of true positives for each immunoassay was 
      determined. Agreement with previously validated GC-MS or LC-MS-MS confirmatory 
      methods was also evaluated. There were 8,825 de-identified screening results for 
      each of the drugs in the panel, except for alcohol (N = 2,296). The percent of 
      samples that screened positive were: 10.0% for 
      amphetamine/methamphetamine/3,4-methylenedioxy-methamphetamine (MDMA), 12.8% for 
      benzodiazepines, 43.7% for opiates (including oxycodone) and 20.3% for 
      tetrahydrocannabinol (THC). The false positive rate for 
      amphetamine/methamphetamine was  approximately 14%,  approximately 34% for opiates (excluding oxycodone), 25% 
      for propoxyphene and 100% for phencyclidine and MDMA immunoassays. Based on the 
      results from this retrospective study, the true positive rate for THC drug use 
      among adults were similar to the rate of illicit drug use in young adults from 
      the 2013 National Survey; however, our positivity rate for cocaine was higher 
      than the National Survey.
CI  - (c) The Author 2015. Published by Oxford University Press. All rights reserved. For 
      Permissions, please email: journals.permissions@oup.com.
FAU - Johnson-Davis, Kamisha L
AU  - Johnson-Davis KL
AD  - University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA ARUP 
      Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA 
      kamisha.johnson-davis@aruplab.com.
FAU - Sadler, Aaron J
AU  - Sadler AJ
AD  - ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, 
      USA.
FAU - Genzen, Jonathan R
AU  - Genzen JR
AD  - University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA ARUP 
      Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151213
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Illicit Drugs)
RN  - 3K9958V90M (Ethanol)
RN  - 44RAL3456C (Methamphetamine)
RN  - 7J8897W37S (Dronabinol)
RN  - CD35PMG570 (Oxycodone)
RN  - CK833KGX7E (Amphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
CIN - J Anal Toxicol. 2017 Apr 1;41(3):258. PMID: 28013286
MH  - Adult
MH  - Amphetamine/immunology/urine
MH  - Chromatography, Liquid
MH  - Cocaine/immunology/urine
MH  - Dronabinol/immunology/urine
MH  - Ethanol/immunology/urine
MH  - False Negative Reactions
MH  - False Positive Reactions
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Illicit Drugs/*immunology/*urine
MH  - *Immunoassay
MH  - Male
MH  - Methamphetamine/immunology/urine
MH  - Middle Aged
MH  - N-Methyl-3,4-methylenedioxyamphetamine/immunology/urine
MH  - Oxycodone/immunology/urine
MH  - Retrospective Studies
MH  - Substance Abuse Detection/*methods
MH  - Young Adult
EDAT- 2015/12/17 06:00
MHDA- 2016/09/27 06:00
CRDT- 2015/12/16 06:00
PHST- 2015/12/16 06:00 [entrez]
PHST- 2015/12/17 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
AID - bkv133 [pii]
AID - 10.1093/jat/bkv133 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2016 Mar;40(2):97-107. doi: 10.1093/jat/bkv133. Epub 2015 Dec 13.