PMID- 26668639
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 10
IP  - 6
DP  - 2015 Dec
TI  - Effect of low-dose diuretics on the level of serum cystatin C and prognosis in 
      patients with asymptomatic chronic heart failure.
PG  - 2345-2350
AB  - The aim of the present study was to investigate the effect of low-dose diuretics 
      on the serum cystatin C (CysC) and serum creatinine (Scr) levels, and on the 
      prognosis in patients with asymptomatic chronic heart failure (HF). A total of 66 
      asymptomatic chronic HF patients were divided into the observation and control 
      groups (n=33 in each group). Patients in the control group were treated with a 
      routine treatment, while the patients in the observation group were treated with 
      the diuretic hydrochlorothiazide along with the same routine treatment as the 
      control group. The left ventricular ejection fraction (LVEF), serum CysC levels, 
      Scr levels, heart function, prognosis, adverse reactions and complications of the 
      patients in the two groups were compared prior to and following treatment. The 
      LVEF increased in the two groups following treatment, while the levels of serum 
      CysC and Scr decreased. The LVEF in the observation group increased following 
      treatment for 1, 3 and 6 months compared with the LVEF values in the control 
      group. In addition, the levels of serum CysC and Scr in the observation group 
      were found to be lower compared with those in the control group (P<0.05). The 
      incidence of adverse prognosis following treatment for 6 months in the 
      observation group was lower compared with that in the control group (P<0.05). The 
      proportion of HF patients with New York Heart Association (NYHA) class I and II 
      increased following treatment for 6 months in the two groups (P<0.05). However, 
      in the observation group, a higher number of patients exhibited class I and II 
      disease after treatment for 6 months compared with the number in the control 
      group (P<0.05). Furthermore, no statistically significant difference was observed 
      between adverse reactions and complications in the two groups (P>0.05). In 
      conclusion, low-dose diuretics may effectively improve the cardiac and renal 
      functions and prognosis in asymptomatic chronic HF patients, without increasing 
      the incidence of side effects.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Department of Cardiology, Henan University Huaihe Hospital, Kaifeng, Henan 
      475000, P.R. China.
FAU - Li, Yanming
AU  - Li Y
AD  - Department of Cardiology, Henan University Huaihe Hospital, Kaifeng, Henan 
      475000, P.R. China.
FAU - Cheng, Guanchang
AU  - Cheng G
AD  - Department of Cardiology, Henan University Huaihe Hospital, Kaifeng, Henan 
      475000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20151030
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC4665351
OTO - NOTNLM
OT  - asymptomatic
OT  - chronic heart failure
OT  - cystatin C
OT  - diuretics
OT  - low dose
EDAT- 2015/12/17 06:00
MHDA- 2015/12/17 06:01
PMCR- 2015/10/30
CRDT- 2015/12/16 06:00
PHST- 2014/10/05 00:00 [received]
PHST- 2015/10/14 00:00 [accepted]
PHST- 2015/12/16 06:00 [entrez]
PHST- 2015/12/17 06:00 [pubmed]
PHST- 2015/12/17 06:01 [medline]
PHST- 2015/10/30 00:00 [pmc-release]
AID - ETM-0-0-2837 [pii]
AID - 10.3892/etm.2015.2837 [doi]
PST - ppublish
SO  - Exp Ther Med. 2015 Dec;10(6):2345-2350. doi: 10.3892/etm.2015.2837. Epub 2015 Oct 
      30.