PMID- 26668647
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 10
IP  - 6
DP  - 2015 Dec
TI  - Correlation analysis of severe aplastic anemia immunosuppressive therapy and 
      human leukocyte antigen alleles in pediatric patients.
PG  - 2396-2402
AB  - The aim of the present study was to investigate the correlation between the 
      efficacy of immunosuppressive therapy (IST) in children with severe aplastic 
      anemia (SAA) and human leukocyte antigen (HLA) alleles. The polymerase chain 
      reaction-sequence based typing high-resolution genotyping method was used to 
      profile the HLA alleles of 115 SAA cases that were treated with 
      rabbit-antithymocyte globulin (r-ATG) + cyclosporine (CsA) immunosuppressive 
      therapy and 222 normal control subjects. The aim was to compare the frequency 
      distribution of HLA alleles among the IST-effective group, the IST-ineffective 
      group and the healthy control group. The results showed that the gene frequencies 
      (GFs) of HLA-B*15:02, B*40:02, B*48:01, DRB1*09:01, C*01:02, C*03:04, DQB1*03:03 
      and DQB1*06:02 in the IST-effective group were significantly higher compared with 
      those in the healthy control group, with a statistically significant difference. 
      The GFs of HLA-B*15:11, B*38:01, B*39:05, DRB1*15:01, C*01:02 and C*08:22 in the 
      IST-ineffective group were significantly increased compared with those in the 
      healthy control group, with a statistically significant difference. The gene 
      frequency of HLA-A*29:01 in the IST-effective group was significantly reduced 
      compared with that in the IST-ineffective group, and the difference was 
      statistically significant. In summary, IST efficacy in children with SAA that 
      express the HLA-B*15:02, B*40:02, B*48:01, DRB1*09:01, C*01:02, C*03:04, 
      DQB1*03:03 and DQB1*06:02 alleles may be superior, while the efficacy may be 
      mitigated in children with SAA who express HLA-A*29:01, B*15:11, B*38:01, 
      B*39:05, DRB1*15:01, C*01:02, C*08:22 alleles.
FAU - Fu, Ru-Ting
AU  - Fu RT
AD  - Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou, Guangdong 510000, P.R. China.
FAU - Xue, Hong-Man
AU  - Xue HM
AD  - Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou, Guangdong 510000, P.R. China.
FAU - Zhang, Bi-Hong
AU  - Zhang BH
AD  - Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou, Guangdong 510000, P.R. China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou, Guangdong 510000, P.R. China.
FAU - Lin, Shao-Fen
AU  - Lin SF
AD  - Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou, Guangdong 510000, P.R. China.
FAU - Chen, Chun
AU  - Chen C
AD  - Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou, Guangdong 510000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20151015
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC4665386
OTO - NOTNLM
OT  - high-resolution
OT  - human leukocyte antigen alleles
OT  - immunosuppressive therapy
OT  - severe aplastic anemia
EDAT- 2015/12/17 06:00
MHDA- 2015/12/17 06:01
PMCR- 2015/10/15
CRDT- 2015/12/16 06:00
PHST- 2014/08/25 00:00 [received]
PHST- 2015/08/20 00:00 [accepted]
PHST- 2015/12/16 06:00 [entrez]
PHST- 2015/12/17 06:00 [pubmed]
PHST- 2015/12/17 06:01 [medline]
PHST- 2015/10/15 00:00 [pmc-release]
AID - ETM-0-0-2807 [pii]
AID - 10.3892/etm.2015.2807 [doi]
PST - ppublish
SO  - Exp Ther Med. 2015 Dec;10(6):2396-2402. doi: 10.3892/etm.2015.2807. Epub 2015 Oct 
      15.