PMID- 26670320
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 26
IP  - 8
DP  - 2016 Aug
TI  - The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and 
      cancer risk estimation in paediatric chest and abdominopelvic CT examinations.
PG  - 2646-55
LID - 10.1007/s00330-015-4091-7 [doi]
AB  - OBJECTIVES: To develop a clinically applicable method to estimate 
      patient-specific organ and blood doses and lifetime attributable risks (LAR) from 
      paediatric torso CT examinations. METHODS: Individualized voxel models were 
      created from full-body CT data of 10 paediatric patients (2-18 years). 
      Patient-specific dose distributions of chest and abdominopelvic CT scans were 
      simulated using Monte Carlo methods. Blood dose was calculated as a weighted sum 
      of simulated organ doses. LAR of cancer incidence and mortality were estimated, 
      according to BEIR-VII. A second simulation and blood dose calculation was 
      performed using only the thoracic and abdominopelvic region of the original voxel 
      models. For each simulation, the size-specific dose estimate (SSDE) was 
      calculated. RESULTS: SSDE showed a significant strong linear correlation with 
      organ dose (r > 0.8) and blood dose (r > 0.9) and LAR (r > 0.9). No significant 
      differences were found between blood dose calculations with the full-body voxel 
      models and the thoracic or abdominopelvic models. CONCLUSION: Even though 
      clinical CT images mostly do not cover the whole body of the patient, they can be 
      used as a voxel model for blood dose calculation. In addition, SSDE can estimate 
      patient-specific organ and blood doses and LAR in paediatric torso CT 
      examinations. KEY POINTS: * Blood dose can be simulated using the patient's 
      clinical CT images. * SSDE estimates patient-specific organ/blood dose and LAR in 
      paediatric CAP CT-examinations. * SSDE makes on-the-spot dose and LAR estimations 
      possible in routine clinical practice.
FAU - Franck, Caro
AU  - Franck C
AD  - Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, 9000, 
      Ghent, Belgium. caro.franck@ugent.be.
FAU - Vandevoorde, Charlot
AU  - Vandevoorde C
AD  - Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, 9000, 
      Ghent, Belgium.
FAU - Goethals, Ingeborg
AU  - Goethals I
AD  - Nuclear Medicine Department, Ghent University Hospital, De Pintelaan 185, 9000, 
      Ghent, Belgium.
FAU - Smeets, Peter
AU  - Smeets P
AD  - Radiology Department, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, 
      Belgium.
FAU - Achten, Eric
AU  - Achten E
AD  - Radiology Department, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, 
      Belgium.
FAU - Verstraete, Koenraad
AU  - Verstraete K
AD  - Radiology Department, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, 
      Belgium.
FAU - Thierens, Hubert
AU  - Thierens H
AD  - Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, 9000, 
      Ghent, Belgium.
FAU - Bacher, Klaus
AU  - Bacher K
AD  - Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, 9000, 
      Ghent, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20151215
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Abdomen/*diagnostic imaging
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Computer Simulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Models, Theoretical
MH  - Monte Carlo Method
MH  - Neoplasms, Radiation-Induced/*epidemiology/etiology
MH  - *Organs at Risk
MH  - Pelvis/*diagnostic imaging
MH  - *Radiation Dosage
MH  - Thorax/*diagnostic imaging
MH  - Tomography, X-Ray Computed/*adverse effects/methods
OTO - NOTNLM
OT  - Monte Carlo method
OT  - Paediatrics
OT  - Patient-specific computational modelling
OT  - Radiation dosimetry
OT  - X-Ray computed tomography
EDAT- 2015/12/17 06:00
MHDA- 2017/02/28 06:00
CRDT- 2015/12/17 06:00
PHST- 2015/05/04 00:00 [received]
PHST- 2015/10/27 00:00 [accepted]
PHST- 2015/10/21 00:00 [revised]
PHST- 2015/12/17 06:00 [entrez]
PHST- 2015/12/17 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
AID - 10.1007/s00330-015-4091-7 [pii]
AID - 10.1007/s00330-015-4091-7 [doi]
PST - ppublish
SO  - Eur Radiol. 2016 Aug;26(8):2646-55. doi: 10.1007/s00330-015-4091-7. Epub 2015 Dec 
      15.