PMID- 26671228
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20221207
IS  - 1871-403X (Print)
IS  - 1871-403X (Linking)
VI  - 10 Suppl 1
DP  - 2016 Sep
TI  - The association of peroxisome proliferator-activated receptor alpha with diabetic 
      retinopathy, and additional gene-obesity interaction in Chinese type 2 diabetes 
      mellitus patients.
PG  - S103-S109
LID - S1871-403X(15)00182-9 [pii]
LID - 10.1016/j.orcp.2015.11.002 [doi]
AB  - AIMS: To investigate the impact of peroxisome proliferator-activated receptor alpha 
      (PPAR alpha) SNPs and gene-obesity interaction on diabetic retinopathy (DR) 
      susceptibility in a Chinese Han population. METHODS: A total of 812 patients 
      (373men, 439 women) with type 2 diabetes mellitus (T2DM), with a mean age of 
      53.3+/-14.0 years old, were selected, including 402 diabetic retinopathy patients 
      and 410 controls. Three single nucleotide polymorphisms (SNPs) were selected for 
      genotyping in the case-control study: rs4253778, rs135539 and rs1800206. 
      Generalised multifactor dimensionality reduction (GMDR) and logistic regression 
      model was used to examine the association and interaction between SNP and obesity 
      on DR, odds ratio (OR) and 95% confident interval (95%CI) were calculated. 
      RESULTS: The carriers of homozygous mutant of rs1800206 SNP revealed decreased DR 
      risk than those with wild-type homozygotes, OR (95%CI) was 0.78 (0.66-0.94). GMDR 
      analysis indicated a significant two-locus model (p=0.0107) involving rs1800206 
      and abdominal obesity, indicating a potential interaction among rs1800206 and 
      abdominal obesity. Overall, the two-locus models had a cross-validation 
      consistency of 10 of 10, and had the testing accuracy of 60.72%. We also found 
      that subjects with abdominal obesity and LV or VV genotype have lowest DR risk, 
      compared to subjects with normal WC and LL genotype, OR (95%CI) was 0.39 
      (0.30-0.74), after covariates adjustment. CONCLUSIONS: Our results support an 
      important association between rs1800206 minor allele of PPAR alpha and DR, and the 
      interaction analysis also shown a combined effect of Leu162 allele-abdominal 
      obesity interaction on DR.
CI  - Copyright (c) 2015 Asia Oceania Association for the Study of Obesity. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Qi, Shounan
AU  - Qi S
AD  - Eye Hospital, The second Hospital of Jilin University, Changchun 130041, China.
FAU - Wang, Chenguang
AU  - Wang C
AD  - Eye Hospital, The second Hospital of Jilin University, Changchun 130041, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Eye Hospital, The second Hospital of Jilin University, Changchun 130041, China.
FAU - Cheng, Yan
AU  - Cheng Y
AD  - Eye Hospital, The second Hospital of Jilin University, Changchun 130041, China.
FAU - Wang, Shurong
AU  - Wang S
AD  - Eye Hospital, The second Hospital of Jilin University, Changchun 130041, China. 
      Electronic address: wangshurong3313@163.com.
FAU - Zhao, Yixuan
AU  - Zhao Y
AD  - Eye Hospital, The second Hospital of Jilin University, Changchun 130041, China.
LA  - eng
PT  - Journal Article
DEP - 20151203
PL  - Netherlands
TA  - Obes Res Clin Pract
JT  - Obesity research & clinical practice
JID - 101303911
RN  - 0 (PPAR alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Diabetic Retinopathy/*etiology/genetics
MH  - Epistasis, Genetic
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Homozygote
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Obesity, Abdominal/*complications
MH  - Odds Ratio
MH  - PPAR alpha/*genetics
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Interaction
OT  - Obesity
OT  - PPAR alpha
EDAT- 2015/12/17 06:00
MHDA- 2017/11/03 06:00
CRDT- 2015/12/17 06:00
PHST- 2015/09/01 00:00 [received]
PHST- 2015/11/01 00:00 [revised]
PHST- 2015/11/06 00:00 [accepted]
PHST- 2015/12/17 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
PHST- 2015/12/17 06:00 [entrez]
AID - S1871-403X(15)00182-9 [pii]
AID - 10.1016/j.orcp.2015.11.002 [doi]
PST - ppublish
SO  - Obes Res Clin Pract. 2016 Sep;10 Suppl 1:S103-S109. doi: 
      10.1016/j.orcp.2015.11.002. Epub 2015 Dec 3.