PMID- 26671515
OWN - NLM
STAT- MEDLINE
DCOM- 20161024
LR  - 20240324
IS  - 1473-5687 (Electronic)
IS  - 0954-691X (Print)
IS  - 0954-691X (Linking)
VI  - 28
IP  - 3
DP  - 2016 Mar
TI  - Role of body composition and metabolic profile in Barrett's oesophagus and 
      progression to cancer.
PG  - 251-60
LID - 10.1097/MEG.0000000000000536 [doi]
AB  - BACKGROUND AND AIMS: The aim of this study was to evaluate the risk for Barrett's 
      oesophagus (BE) on the basis of body composition, metabolic pathways, adipokines 
      and metabolic syndrome (MS), as well as their role in cancer progression. 
      METHODS: In patients with and without BE at gastroscopy, data on MS, BMI, 
      waist/hip ratio for abdominal obesity (AO) and body fat percentage by 
      bioimpedance were obtained. Fasting plasma glucose, insulin, HbA1c, lipid, serum 
      adiponectin and leptin levels were measured. The homoeostasis model assessment 
      (HOMA-IR) was used to estimate insulin resistance. Histological findings for BE 
      were correlated with the above parameters. Risk factors for BE identified using 
      univariate analysis were entered into a multivariate logistic regression 
      analysis. RESULTS: A total of 250 patients and 224 controls (F/M: 189/285, mean 
      age 58.08+/-15.51 years) were enroled. In the BE and control groups, 39.6 versus 
      31.3% were overweight, 32 versus 22.8% were obese, 75.6 versus 51.3% had AO, and 
      28.1 versus 18.9% were metabolically obese, respectively. AO [odds ratio (OR) 
      3.08], increased body fat percentage (OR 2.29), and higher BMI (overweight: OR 
      2.04; obese: OR 2.26) were significantly associated with BE. A positive trend was 
      found in Normal Weight Obese Syndrome (OR 1.69). MS was associated with BE 
      (overweight: OR 3.05; obese: OR 5.2; AO: OR 8.08). Insulin levels (P=0.05) and 
      HOMA-IR (P<0.001) were higher in BE. AO was the only independent risk factor 
      associated with BE (OR 1.65; P=0.02) and high-grade dysplasia (OR 2.44) on 
      multivariate analysis. CONCLUSION: AO was strongly associated with BE and 
      dysplasia. BE was associated with MS and higher insulin/HOMA-IR, suggesting the 
      activation of specific metabolic pathways in patients with altered body 
      composition.
FAU - Di Caro, Simona
AU  - Di Caro S
AD  - Departments of aGastroenterology bMedicine, Centre for Obesity Research, 
      University College London Hospital, London, UK cDepartment of Gastroenterology, 
      Busto Arstizio Hospital, Milan dDepartment of Neuroscience, Tor Vergata 
      University, Rome, Italy.
FAU - Cheung, Wui Hang
AU  - Cheung WH
FAU - Fini, Lucia
AU  - Fini L
FAU - Keane, Margaret G
AU  - Keane MG
FAU - Theis, Belinda
AU  - Theis B
FAU - Haidry, Rehan
AU  - Haidry R
FAU - Di Renzo, Laura
AU  - Di Renzo L
FAU - De Lorenzo, Antonino
AU  - De Lorenzo A
FAU - Lovat, Laurence
AU  - Lovat L
FAU - Batterham, Rachel L
AU  - Batterham RL
FAU - Banks, Matthew
AU  - Banks M
LA  - eng
GR  - RP-2015-06-005/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (Adipokines)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (hemoglobin A1c protein, human)
RN  - Adenocarcinoma Of Esophagus
SB  - IM
MH  - Adenocarcinoma/*epidemiology/pathology
MH  - Adipokines/blood
MH  - *Adiposity
MH  - Adult
MH  - Aged
MH  - Barrett Esophagus/*epidemiology/pathology
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Disease Progression
MH  - Esophageal Neoplasms/*epidemiology/pathology
MH  - Female
MH  - Gastroscopy
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin/blood
MH  - Lipids/blood
MH  - Logistic Models
MH  - London/epidemiology
MH  - Male
MH  - Metabolic Syndrome/*blood/diagnosis/epidemiology
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Obesity, Abdominal/diagnosis/epidemiology/*physiopathology
MH  - Odds Ratio
MH  - Precancerous Conditions/*epidemiology/pathology
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Waist-Hip Ratio
PMC - PMC4739314
EDAT- 2015/12/17 06:00
MHDA- 2016/10/25 06:00
PMCR- 2016/02/03
CRDT- 2015/12/17 06:00
PHST- 2015/12/17 06:00 [entrez]
PHST- 2015/12/17 06:00 [pubmed]
PHST- 2016/10/25 06:00 [medline]
PHST- 2016/02/03 00:00 [pmc-release]
AID - 10.1097/MEG.0000000000000536 [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2016 Mar;28(3):251-60. doi: 
      10.1097/MEG.0000000000000536.