PMID- 26673898
OWN - NLM
STAT- MEDLINE
DCOM- 20160630
LR  - 20220408
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 12
DP  - 2015
TI  - Economic Analysis of Immunization Strategies for PRRS Control [corrected].
PG  - e0144265
LID - 10.1371/journal.pone.0144265 [doi]
LID - e0144265
AB  - Porcine reproductive and respiratory syndrome virus (PRRSv) is a swine-specific 
      pathogen that causes significant increases in production costs. When a breeding 
      herd becomes infected, in an attempt to hasten control and elimination of PRRSv, 
      some veterinarians have adopted a strategy called load-close-expose which 
      consists of interrupting replacement pig introductions into the herd for several 
      weeks (herd closure) and exposing the whole herd to a replicating PRRSv to boost 
      herd immunity. Either modified-live virus (MLV) vaccine or live field-virus 
      inoculation (FVI) is used. This study consisted of partial budget analyses to 
      compare MLV to FVI as the exposure method of load-close-expose program to control 
      and eliminate PRRSv from infected breeding herds, and secondly to estimate 
      benefit / cost of vaccinating sow herds preventatively. Under the assumptions 
      used in this study, MLV held economic advantage over FVI. However, sensitivity 
      analysis revealed that decreasing margin over variable costs below $ 47.32, or 
      increasing PRRSv-attributed cost above $18.89 or achieving time-to-stability 
      before 25 weeks resulted in advantage of FVI over MLV. Preventive vaccination of 
      sow herds was beneficial when the frequency of PRRSv infection was at least every 
      1 year and 9 months [corrected]. The economics of preventative vaccination was 
      minimally affected by cost attributed to field-type PRRSv infection on growing 
      pigs or by the breeding herd productivity level. The models developed and 
      described in this paper provide valuable tools to assist veterinarians in their 
      efforts to control PRRSv.
FAU - Linhares, Daniel C L
AU  - Linhares DC
AD  - Veterinary Diagnostic and Production Animal Medicine Department, College of 
      Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America.
FAU - Johnson, Clayton
AU  - Johnson C
AD  - Swine Health Department, The Maschhoffs LLC, Carlyle, Illinois, United States of 
      America.
FAU - Morrison, Robert B
AU  - Morrison RB
AD  - Department of Veterinary Population Medicine, College of Veterinary Medicine, 
      University of Minnesota, Saint Paul, Minnesota, United States of America.
LA  - eng
PT  - Journal Article
DEP - 20151216
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Viral Vaccines)
SB  - IM
EIN - PLoS One. 2016;11(4):e0150444. PMID: 27088727
MH  - Animals
MH  - Models, Theoretical
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
MH  - Vaccination/*economics/*methods
MH  - Viral Vaccines/*immunology
PMC - PMC4682627
COIS- Competing Interests: CJ was employed by The Maschhoffs, LLC. This did not alter 
      the authors' adherence to PLOS ONE policies on sharing data and materials.
EDAT- 2015/12/18 06:00
MHDA- 2016/07/01 06:00
PMCR- 2015/12/16
CRDT- 2015/12/18 06:00
PHST- 2015/05/31 00:00 [received]
PHST- 2015/11/16 00:00 [accepted]
PHST- 2015/12/18 06:00 [entrez]
PHST- 2015/12/18 06:00 [pubmed]
PHST- 2016/07/01 06:00 [medline]
PHST- 2015/12/16 00:00 [pmc-release]
AID - PONE-D-15-23641 [pii]
AID - 10.1371/journal.pone.0144265 [doi]
PST - epublish
SO  - PLoS One. 2015 Dec 16;10(12):e0144265. doi: 10.1371/journal.pone.0144265. 
      eCollection 2015.