PMID- 26674628
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20191210
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 54
IP  - 8
DP  - 2015 Aug
TI  - [The value of chest computerized tomography in evaluation of bone disease and 
      clinical prognosis of multiple myeloma].
PG  - 711-5
AB  - OBJECTIVE: To assess the status and severity of bone disease in patients with 
      multiple myeloma (MM) by using chest computerized tomography (CT) and the 
      relationship between clinical prognostic parameters and bone disease. METHODS: 
      All 46 newly diagnosed MM in-patients received both imaging tests of chest CT and 
      plain X ray. An experienced radiologist reviewed all the imaging data. Clinical 
      laboratory parameters, stages of Durie-Salmon (DS) and International Staging 
      System (ISS) were evaluated. Five cytogenetic abnormalities of bone marrow 
      myeloma cells were tested by fluorescence in situ hybridization (FISH). RESULTS: 
      The sensitivity of CT and X ray to determine pathological fractures was 
      comparable, the positive rates of which were 41.3% (19/46) and 30.4% (14/46) 
      respectively (P = 0.29). Nevertheless, the positive rate of osteolytic lesions 
      ascertained by CT was significantly higher than that by X ray (P < 0.001), 60.9% 
      (28/46) vs 13.0% (6/46) with diameter 5-10 mm and 50.0% (23/46) vs 10.9% (5/46) 
      with diameter more than 10 mm. Osteolytic lesion numbers found by CT were more 
      than those by X ray [5(0-21) vs 0(0-4) lesions with diameter 5-10 mm (P < 0.001), 
      2(0-14) vs 0(0-2) lesions with diameter more than 10 mm (P < 0.001), 
      respectively]. Patients with positive osteolytic lesions had higher percentage of 
      RB1 gene deletion [46.7% (14/30) vs 18.8% (3/16), P < 0.001], D13s319 deletion 
      [43.3% (13/30) vs 18.8% (3/16), P < 0.001] and high risk cytogenetic 
      abnormalities [50.0% (15/30) vs 25.0% (4/16), P < 0.001]. CONCLUSIONS: Chest CT 
      is more sensitive than plain X ray in detecting osteolytic myeloma bone disease. 
      Osteolysis determined by CT is relevant to clinical DS stages and risk 
      stratification of cytogenetic abnormalities.
FAU - Tang, Wenjiao
AU  - Tang W
FAU - Da, Yi
AU  - Da Y
FAU - Lin, Qiang
AU  - Lin Q
FAU - Li, Hui
AU  - Li H
FAU - Gao, Xin
AU  - Gao X
FAU - Zhou, Daobin
AU  - Zhou D
FAU - Zhuang, Junling
AU  - Zhuang J
AD  - Department of Hematology, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China; 
      Email: zhuangjunling@pumch.cn.
LA  - chi
PT  - Evaluation Study
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Bone Diseases/*diagnosis/diagnostic imaging
MH  - Chromosome Aberrations
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Multiple Myeloma/*diagnosis/diagnostic imaging/genetics
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2015/12/18 06:00
MHDA- 2016/01/14 06:00
CRDT- 2015/12/18 06:00
PHST- 2015/12/18 06:00 [entrez]
PHST- 2015/12/18 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2015 Aug;54(8):711-5.