PMID- 26675251
OWN - NLM
STAT- MEDLINE
DCOM- 20160913
LR  - 20181113
IS  - 2047-9980 (Electronic)
IS  - 2047-9980 (Linking)
VI  - 4
IP  - 12
DP  - 2015 Dec 16
TI  - Relation Between Circulating Inflammatory Chemokines and Vascular Characteristics 
      in Healthy, Young Children.
LID - 10.1161/JAHA.115.002346 [doi]
LID - e002346
AB  - BACKGROUND: Atherosclerosis begins in childhood with the occurrence of 
      inflammatory vascular wall alterations that are detectable with B-mode 
      ultrasound. Chemokines appear to be involved in the development of these 
      alterations given that they occur early in the atherosclerotic pathway as 
      mediators of vascular inflammation. However, this has not extensively been 
      investigated. Therefore, we studied in healthy young children whether chemokines 
      monocyte chemotactic protein 1 (MCP-1), regulated on activation normal T-cell 
      expressed and secreted (RANTES), and vascular and intercellular adhesion 
      molecules (VCAM and ICAM) related to vascular characteristics of the carotid 
      artery. METHODS AND RESULTS: We obtained demography, anthropometry, and overnight 
      fasting plasma of 139 eight-year-old children of the Wheezing Illnesses Study 
      Leidsche Rijn birth cohort. Carotid intima-media thickness (CIMT), 
      distensibility, and Young's Elastic Modulus (YEM) of the common carotid artery 
      were measured sonographically. Chemokine plasma levels were assessed using a 
      multiplex assay. We studied the relation between the chemokines and vascular 
      characteristics using multivariable linear regression analyses with adjustments 
      for sex, systolic blood pressure, homeostasis model assessment of insulin 
      resistance, triglycerides, low-density lipoprotein- and high-density 
      lipoprotein-cholesterol. Of the studied chemokines, RANTES related to common 
      carotid distensibility and YEM. One standard deviation increase in RANTES level 
      related to a 5.45-MPA(-1) (95% confidence interval [CI], -9.43, -1.39; P=0.01) 
      decrease in distensibility and to a 5.55-kPa increase in YEM (95% CI, 0.40, 
      10.85; P=0.03). RANTES did not relate to CIMT. MCP-1, VCAM, and ICAM did not 
      relate to any of the studied vascular characteristics. CONCLUSION: RANTES appears 
      to be involved in the development of preatherosclerotic inflammatory vascular 
      alterations already in healthy, young children. This may provide further insight 
      into the early-life origins of atherosclerosis.
CI  - (c) 2015 The Authors. Published on behalf of the American Heart Association, Inc., 
      by Wiley Blackwell.
FAU - Eikendal, Anouk L M
AU  - Eikendal AL
AD  - Department of Radiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands (A.M.E.).
FAU - Evelein, Annemieke M V
AU  - Evelein AM
AD  - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical 
      Center Utrecht, Utrecht, The Netherlands (A.V.E., C.K.E.).
FAU - Uiterwaal, Cuno S P M
AU  - Uiterwaal CS
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, Utrecht, The Netherlands (C.M.U., M.L.B., G.W.D.).
FAU - van der Ent, Cornelis K
AU  - van der Ent CK
AD  - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical 
      Center Utrecht, Utrecht, The Netherlands (A.V.E., C.K.E.).
FAU - Visseren, Frank L J
AU  - Visseren FL
AD  - Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The 
      Netherlands (F.J.V.).
FAU - Bots, Michiel L
AU  - Bots ML
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, Utrecht, The Netherlands (C.M.U., M.L.B., G.W.D.).
FAU - Hoefer, Imo E
AU  - Hoefer IE
AD  - Laboratory of Experimental Cardiology, University Medical Center Utrecht, 
      Utrecht, The Netherlands (I.E.H., H.M.R.).
FAU - den Ruijter, Hester M
AU  - den Ruijter HM
AD  - Laboratory of Experimental Cardiology, University Medical Center Utrecht, 
      Utrecht, The Netherlands (I.E.H., H.M.R.).
FAU - Dalmeijer, Geertje W
AU  - Dalmeijer GW
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, Utrecht, The Netherlands (C.M.U., M.L.B., G.W.D.).
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151216
PL  - England
TA  - J Am Heart Assoc
JT  - Journal of the American Heart Association
JID - 101580524
RN  - 0 (CCL2 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Triglycerides)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
SB  - IM
MH  - Atherosclerosis/etiology
MH  - Blood Pressure
MH  - Carotid Artery, Common/anatomy & histology/*diagnostic imaging
MH  - Carotid Intima-Media Thickness
MH  - Cell Adhesion Molecules/blood
MH  - Chemokine CCL2/blood
MH  - Chemokine CCL5/blood
MH  - Chemokines/*blood
MH  - Child
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Lipoproteins, HDL/blood
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Triglycerides/blood
MH  - Vascular Cell Adhesion Molecule-1/blood
PMC - PMC4845277
OTO - NOTNLM
OT  - arteriosclerosis
OT  - inflammation
OT  - pediatrics
OT  - risk factors
OT  - ultrasonography
EDAT- 2015/12/18 06:00
MHDA- 2016/09/14 06:00
PMCR- 2015/12/01
CRDT- 2015/12/18 06:00
PHST- 2015/12/18 06:00 [entrez]
PHST- 2015/12/18 06:00 [pubmed]
PHST- 2016/09/14 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - JAHA.115.002346 [pii]
AID - JAH31201 [pii]
AID - 10.1161/JAHA.115.002346 [doi]
PST - epublish
SO  - J Am Heart Assoc. 2015 Dec 16;4(12):e002346. doi: 10.1161/JAHA.115.002346.