PMID- 26675268
OWN - NLM
STAT- MEDLINE
DCOM- 20171026
LR  - 20181202
IS  - 1579-2021 (Electronic)
IS  - 1575-0922 (Linking)
VI  - 63
IP  - 2
DP  - 2016 Feb
TI  - Differences in clinical and biological characteristics and prevalence of chronic 
      complications related to aging in patients with type 2 diabetes.
PG  - 79-86
LID - S1575-0922(15)00279-X [pii]
LID - 10.1016/j.endonu.2015.10.005 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a chronic, highly prevalent disease that 
      increases with age. Because of this, and due to its chronic complications, T2DM 
      causes high human, social, and financial costs. In addition, the elderly 
      population with T2DM has a marked clinical heterogeneity. Therefore, our main 
      objective was to analyze the relationship of age with the clinical and biological 
      manifestations of the disease and the prevalence of chronic complications in 
      patients with T2DM. MATERIAL AND METHODS: A cross-sectional study of a large 
      population with T2DM (n=405) randomly selected from a Diabetes Unit and 2 health 
      care centers (60%). The clinical, anthropometric, and biochemical variables of 
      the subjects were collected using standard methods to assess the effect of age on 
      the clinical and biochemical phenotype of patients with T2DM. RESULTS: We have 
      noted that patients with T2DM > 70 years old have a clinical and biochemical 
      phenotype different from younger subjects (<60 years) including longer times 
      since diabetes onset, higher diastolic blood pressure levels, and lower body mass 
      index (BMI) values. As regards to biological variables, these patients have lower 
      triglyceride levels, impaired kidney function, and lower HbA1c values. Prevalence 
      of metabolic syndrome is lower in patients with T2DM > 70 years of age. Age was 
      inversely related to parameters associated to metabolic syndrome (BMI, waist 
      circumference, blood pressure, and triglyceride levels). CONCLUSIONS: We have 
      defined the clinical and biochemical profile of patients with T2DM > 70 years 
      attending health care centers. In addition, the prevalence of stroke, kidney 
      disease, and distal symmetrical polyneuropathy is higher in patients with T2DM 
      >70 years as compared to younger patients (<60 years).
CI  - Copyright (c) 2015 SEEN. Published by Elsevier Espana, S.L.U. All rights reserved.
FAU - Basanta-Alario, Maria Luisa
AU  - Basanta-Alario ML
AD  - Departamento de Fisioterapia, Universitat de Valencia, Valencia, Espana.
FAU - Ferri, Jordi
AU  - Ferri J
AD  - Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario de 
      Valencia, Valencia, Espana. Electronic address: ferrisss@hotmail.com.
FAU - Civera, Miguel
AU  - Civera M
AD  - Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario de 
      Valencia, Valencia, Espana.
FAU - Martinez-Hervas, Sergio
AU  - Martinez-Hervas S
AD  - Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario de 
      Valencia, Valencia, Espana; Departamento de Medicina, Universitat de Valencia, 
      CIBERDEM e INCLIVA, Valencia, Espana.
FAU - Ascaso, Juan Francisco
AU  - Ascaso JF
AD  - Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario de 
      Valencia, Valencia, Espana; Departamento de Medicina, Universitat de Valencia, 
      CIBERDEM e INCLIVA, Valencia, Espana.
FAU - Real, Jose Tomas
AU  - Real JT
AD  - Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario de 
      Valencia, Valencia, Espana; Departamento de Medicina, Universitat de Valencia, 
      CIBERDEM e INCLIVA, Valencia, Espana.
LA  - eng
LA  - spa
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151207
PL  - Spain
TA  - Endocrinol Nutr
JT  - Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y 
      Nutricion
JID - 100886482
RN  - 0 (Triglycerides)
SB  - IM
MH  - *Age Factors
MH  - Aged
MH  - Blood Pressure
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/epidemiology
MH  - Middle Aged
MH  - Prevalence
MH  - Triglycerides/blood
MH  - Waist Circumference
OTO - NOTNLM
OT  - Anciano
OT  - Chronic diabetic complications
OT  - Clinical and biochemical profile
OT  - Complicaciones cronicas de la diabetes
OT  - Diabetes tipo 2
OT  - Elderly
OT  - Metabolic syndrome
OT  - Perfil clinico biologico
OT  - Sindrome metabolico
OT  - Type 2 diabetes mellitus
EDAT- 2015/12/18 06:00
MHDA- 2017/10/27 06:00
CRDT- 2015/12/18 06:00
PHST- 2015/06/28 00:00 [received]
PHST- 2015/10/05 00:00 [revised]
PHST- 2015/10/05 00:00 [accepted]
PHST- 2015/12/18 06:00 [entrez]
PHST- 2015/12/18 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
AID - S1575-0922(15)00279-X [pii]
AID - 10.1016/j.endonu.2015.10.005 [doi]
PST - ppublish
SO  - Endocrinol Nutr. 2016 Feb;63(2):79-86. doi: 10.1016/j.endonu.2015.10.005. Epub 
      2015 Dec 7.