PMID- 26675331
OWN - NLM
STAT- MEDLINE
DCOM- 20161215
LR  - 20161230
IS  - 1477-0377 (Electronic)
IS  - 1358-863X (Linking)
VI  - 21
IP  - 2
DP  - 2016 Apr
TI  - Coronary endothelial dysfunction in non-obstructive coronary artery disease: 
      Risk, pathogenesis, diagnosis and therapy.
PG  - 146-55
LID - 10.1177/1358863X15618268 [doi]
AB  - Up to half of patients with signs and symptoms of stable ischemic heart disease 
      have non-obstructive coronary artery disease (NoCAD). Recent evidence 
      demonstrates that two-thirds of patients with NoCAD have demonstrable coronary 
      endothelial dysfunction represented by microvascular or diffuse epicardial spasm 
      following acetylcholine challenge. Patients with coronary endothelial dysfunction 
      are recognized to have significant health services use and morbidity as well as 
      increased risk of developing flow-limiting coronary artery disease and myocardial 
      events, including death. Currently, there are few centers that test for this 
      etiology owing to lack of knowledge, limited evidence for treatment options and 
      invasive diagnostic strategies. This article reviews the pathophysiology, 
      epidemiology, diagnosis and treatment of coronary endothelial dysfunction as a 
      subgroup of NoCAD.
CI  - (c) The Author(s) 2015.
FAU - Shaw, Jeffrey
AU  - Shaw J
AD  - Department of Cardiac Sciences, University of Calgary, Faculty of Medicine Health 
      Sciences Centre, Calgary, Alberta, Canada jashaw@ucalgary.ca.
FAU - Anderson, Todd
AU  - Anderson T
AD  - Department of Cardiac Sciences, University of Calgary, Faculty of Medicine Health 
      Sciences Centre, Calgary, Alberta, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151215
PL  - England
TA  - Vasc Med
JT  - Vascular medicine (London, England)
JID - 9610930
SB  - IM
MH  - Coronary Artery Disease/diagnosis/epidemiology/*physiopathology/therapy
MH  - Coronary Circulation
MH  - Coronary Vessels/*physiopathology
MH  - Endothelium, Vascular/*physiopathology
MH  - Humans
MH  - Microcirculation
MH  - Microvascular Angina/diagnosis/epidemiology/*physiopathology/therapy
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Vasoconstriction
OTO - NOTNLM
OT  - Cardiac syndrome X
OT  - NoCAD
OT  - chest pain syndromes
OT  - coronary artery disease
OT  - endothelial dysfunction
OT  - microvascular angina
EDAT- 2015/12/18 06:00
MHDA- 2016/12/16 06:00
CRDT- 2015/12/18 06:00
PHST- 2015/12/18 06:00 [entrez]
PHST- 2015/12/18 06:00 [pubmed]
PHST- 2016/12/16 06:00 [medline]
AID - 1358863X15618268 [pii]
AID - 10.1177/1358863X15618268 [doi]
PST - ppublish
SO  - Vasc Med. 2016 Apr;21(2):146-55. doi: 10.1177/1358863X15618268. Epub 2015 Dec 15.