PMID- 26675952
OWN - NLM
STAT- MEDLINE
DCOM- 20160421
LR  - 20231213
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 116
IP  - 1
DP  - 2016 Jan
TI  - No evidence for contraindications to the use of propofol in adults allergic to 
      egg, soy or peanutdagger.
PG  - 77-82
LID - 10.1093/bja/aev360 [doi]
AB  - BACKGROUND: Propofol is thought to be a potential cause of allergic reactions in 
      patients allergic to egg, soy or peanut, since current formulations contain an 
      emulsion that includes egg lecithin and soybean oil. However, other than six case 
      reports lacking in confirmatory evidence of an allergic reaction, there is no 
      evidence linking the two types of allergies. The aim of this study was to examine 
      the frequency of propofol allergy and to investigate if patients with specific 
      immunoglobulin E (IgE) to egg, soy or peanut tolerated propofol. METHODS: Study A 
      examined the frequency of propofol allergy in 273 patients systematically 
      investigated for suspected perioperative allergic reactions. Of these, 153 had 
      been exposed to propofol and underwent skin tests and intravenous provocation. 
      Study B retrospectively investigated propofol exposure and tolerance in 520 adult 
      patients with a positive specific IgE to egg, soy or peanut. RESULTS: Four of the 
      153 propofol-exposed patients (2.6%) investigated in study A were diagnosed with 
      propofol allergy. Of these, three tested positive only on intravenous 
      provocation. None of the four had allergic symptoms when eating egg, soy or 
      peanut and none had detectable levels of specific IgE to egg or soy in their 
      serum. In study B we found no signs of allergic reactions towards propofol in 171 
      retrieved anaesthetic charts from 99 patients with specific IgE to egg, soy or 
      peanut. CONCLUSION: No connection between allergy to propofol and allergy to egg, 
      soy or peanut was found. The present practice of choosing alternatives to 
      propofol in patients with this kind of food allergy is not evidence based and 
      should be reconsidered.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of the British 
      Journal of Anaesthesia. All rights reserved. For Permissions, please email: 
      journals.permissions@oup.com.
FAU - Asserhoj, L L
AU  - Asserhoj LL
AD  - Danish Anaesthesia Allergy Centre (DAAC), Allergy Clinic UA-816, Copenhagen 
      University Hospital, Gentofte, Kildegardsvej 28, 2900 Hellerup, Denmark 
      louise_smil@hotmail.com.
FAU - Mosbech, H
AU  - Mosbech H
AD  - Danish Anaesthesia Allergy Centre (DAAC), Allergy Clinic UA-816, Copenhagen 
      University Hospital, Gentofte, Kildegardsvej 28, 2900 Hellerup, Denmark.
FAU - Kroigaard, M
AU  - Kroigaard M
AD  - Danish Anaesthesia Allergy Centre (DAAC), Allergy Clinic UA-816, Copenhagen 
      University Hospital, Gentofte, Kildegardsvej 28, 2900 Hellerup, Denmark.
FAU - Garvey, L H
AU  - Garvey LH
AD  - Danish Anaesthesia Allergy Centre (DAAC), Allergy Clinic UA-816, Copenhagen 
      University Hospital, Gentofte, Kildegardsvej 28, 2900 Hellerup, Denmark.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adult
MH  - Anesthesia, Intravenous/*adverse effects
MH  - Drug Hypersensitivity/blood/*complications/immunology
MH  - Egg Hypersensitivity/blood/complications/immunology
MH  - Female
MH  - Food Hypersensitivity/blood/*complications/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Peanut Hypersensitivity/blood/complications/immunology
MH  - Propofol/*adverse effects
MH  - Retrospective Studies
MH  - Skin Tests/statistics & numerical data
MH  - Glycine max/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - anaphylaxis
OT  - egg hypersensitivity
OT  - i.v. anaesthetics, propofol
OT  - peanut hypersensitivity
OT  - soybean oil
EDAT- 2015/12/18 06:00
MHDA- 2016/04/22 06:00
CRDT- 2015/12/18 06:00
PHST- 2015/12/18 06:00 [entrez]
PHST- 2015/12/18 06:00 [pubmed]
PHST- 2016/04/22 06:00 [medline]
AID - S0007-0912(17)30526-3 [pii]
AID - 10.1093/bja/aev360 [doi]
PST - ppublish
SO  - Br J Anaesth. 2016 Jan;116(1):77-82. doi: 10.1093/bja/aev360.