PMID- 26676294
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151218
LR  - 20151217
IS  - 1757-5664 (Print)
IS  - 1757-5664 (Linking)
VI  - 2
IP  - 2
DP  - 2010 Sep
TI  - Effects of alpha1-Blockers for Lower Urinary Tract Symptoms and Sleep Disorders in 
      Patients with Benign Prostatic Hyperplasia.
PG  - 119-22
LID - 10.1111/j.1757-5672.2010.00073.x [doi]
AB  - OBJECTIVES: We evaluated the association of lower urinary tract symptoms (LUTS) 
      and sleep disorders (SD) in patients with benign prostatic hyperplasia (BPH). We 
      also examined improvement of SD following the alpha1-blocker therapy for LUTS. 
      METHODS: Sixty-eight male patients were enrolled in the study, consisting of 38 
      cases with LUTS and BPH (BPH group), and 30 men without significant LUTS or BPH 
      (non-BPH group). The degree of LUTS and SD was evaluated by the International 
      Prostate Symptom Score and the Pittsburg Sleep Quality Index (PSQI), 
      respectively. The patients of BPH group then were treated with alpha1-blocker for 4 
      weeks, and were re-examined by all the questionnaires to evaluate the therapeutic 
      efficacies. RESULTS: The correlation analyses showed a significant association of 
      LUTS with SD in BPH group (r = 0.4995, P = 0.0068). Twenty cases (52.6%) in BPH 
      group showed 5.5 or more PSQI scores. Following 4 weeks of alpha1-blocker 
      administration, the average PSQI decreased significantly from 6.3 to 4.8 points 
      (P < 0.001). Significant improvement was observed in domains of "sleep quality" 
      and "sleep disturbances" among PSQI (P = 0.0215 and 0.0391, respectively). 
      Moreover, significant association between alpha1-blocker induced improvements of 
      nocturia and SD was identified in patients with 5.5 or more PSQI score at 
      baseline (r = 0.445, P = 0.0334). CONCLUSION: These results suggested that SD is 
      associated with LUTS among BPH patients and therapeutic effects of alpha1-blockers on 
      LUTS lead to improvements of SD.
CI  - (c) 2010 Blackwell Publishing Asia Pty Ltd.
FAU - Sakuma, Takahiro
AU  - Sakuma T
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, 
      JapanDepartment of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Sato, Katsuhiko
AU  - Sato K
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, 
      JapanDepartment of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Nagane, Yusuke
AU  - Nagane Y
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, 
      JapanDepartment of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Mochida, Junichi
AU  - Mochida J
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, 
      JapanDepartment of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Sugimoto, Shuji
AU  - Sugimoto S
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, 
      JapanDepartment of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Ichinose, Taketo
AU  - Ichinose T
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, 
      JapanDepartment of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Yamaguchi, Kenya
AU  - Yamaguchi K
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, 
      JapanDepartment of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Uchiyama, Makoto
AU  - Uchiyama M
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, 
      JapanDepartment of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Takahashi, Satoru
AU  - Takahashi S
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, 
      JapanDepartment of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20100705
PL  - Australia
TA  - Low Urin Tract Symptoms
JT  - Lower urinary tract symptoms
JID - 101506777
OTO - NOTNLM
OT  - benign prostatic hyperplasia
OT  - sleep disorders
OT  - alpha1-blocker
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2015/12/18 06:00
PHST- 2015/12/18 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
AID - 10.1111/j.1757-5672.2010.00073.x [doi]
PST - ppublish
SO  - Low Urin Tract Symptoms. 2010 Sep;2(2):119-22. doi: 
      10.1111/j.1757-5672.2010.00073.x. Epub 2010 Jul 5.