PMID- 26676568
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20231213
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 53
IP  - 10
DP  - 2016 Dec
TI  - Sex-Specific Effects of Prenatal Stress on Bdnf Expression in Response to an 
      Acute Challenge in Rats: a Role for Gadd45beta.
PG  - 7037-7047
AB  - Exposure to early adversities represents a major risk factor for psychiatric 
      disorders. We have previously shown that exposure to prenatal stress (PNS) in 
      rats alters the developmental expression of brain-derived neurotrophic factor 
      (Bdnf) with a specific temporal profile. However, exposure to early-life stress 
      is known to alter the ability to cope with challenging events later in life, 
      which may contribute to the enhanced vulnerability to stress-related disorders. 
      Since Bdnf is also an important player for activity-dependent plasticity, we 
      investigated whether the exposure to PNS in rats could alter Bdnf responsiveness 
      to an acute challenge at adulthood. We found that exposure to PNS produces 
      significant changes in Bdnf responsiveness with brain region- and gender-specific 
      selectivity. Indeed, exposure to an acute stress upregulates Bdnf expression in 
      the prefrontal cortex, but not in the hippocampus, of control animals. Moreover, 
      such modulatory activity is selectively impaired in PNS female rats, an effect 
      that was associated with changes in the modulation of the DNA demethylase 
      Gadd45beta. Our results suggest that exposure to PNS may reprogram gene 
      transcription through epigenetic mechanisms reducing the ability to cope under 
      adverse conditions, a trait that is disrupted in psychiatric diseases.
FAU - Luoni, A
AU  - Luoni A
AD  - Department of Pharmacological and Biomolecular Sciences, University of Milan, via 
      Balzaretti 9, 20133, Milan, Italy.
FAU - Berry, A
AU  - Berry A
AD  - Section of Behavioural Neurosciences, Department of Cell Biology and 
      Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, 
      Italy.
FAU - Raggi, C
AU  - Raggi C
AD  - Section of Behavioural Neurosciences, Department of Cell Biology and 
      Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, 
      Italy.
FAU - Bellisario, V
AU  - Bellisario V
AD  - Section of Behavioural Neurosciences, Department of Cell Biology and 
      Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, 
      Italy.
FAU - Cirulli, F
AU  - Cirulli F
AD  - Section of Behavioural Neurosciences, Department of Cell Biology and 
      Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, 
      Italy.
FAU - Riva, M A
AU  - Riva MA
AD  - Department of Pharmacological and Biomolecular Sciences, University of Milan, via 
      Balzaretti 9, 20133, Milan, Italy. M.Riva@unimi.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151216
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Glucocorticoid)
SB  - IM
MH  - Aging/metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Female
MH  - Gene Expression Regulation
MH  - Intracellular Signaling Peptides and Proteins/*metabolism
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*genetics/pathology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptors, Glucocorticoid/metabolism
MH  - *Sex Characteristics
MH  - Stress, Physiological/genetics
MH  - Transcription, Genetic
MH  - GADD45 Proteins
OTO - NOTNLM
OT  - Acute stress
OT  - Bdnf
OT  - Gadd45beta
OT  - Gender effect
OT  - Prenatal restraint stress
EDAT- 2015/12/18 06:00
MHDA- 2017/12/23 06:00
CRDT- 2015/12/18 06:00
PHST- 2015/09/22 00:00 [received]
PHST- 2015/11/29 00:00 [accepted]
PHST- 2015/12/18 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
PHST- 2015/12/18 06:00 [entrez]
AID - 10.1007/s12035-015-9569-4 [pii]
AID - 10.1007/s12035-015-9569-4 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2016 Dec;53(10):7037-7047. doi: 10.1007/s12035-015-9569-4. Epub 
      2015 Dec 16.