PMID- 26679085
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20220310
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 6
IP  - 4
DP  - 2016 Apr
TI  - Nonselective chemokine levels in nasal secretions of patients with perennial 
      nonallergic and allergic rhinitis.
PG  - 392-7
LID - 10.1002/alr.21684 [doi]
AB  - BACKGROUND: An increased production of several chemoattractants, responsible for 
      guiding the eosinophilic inflammatory process, has been reported in chronic 
      rhinitis. The aim of this study was to evaluate nasal secretion levels of 
      monocyte chemoattractant protein-1 (MCP-1), MCP-3, and regulated on activation 
      normal T cell expressed and secreted (RANTES) and to correlate those levels with 
      nasal symptoms and degree of eosinophilia in patients with nonallergic rhinitis 
      with eosinophilia syndrome (NARES) and perennial allergic rhinitis (PAR). 
      METHODS: Fourteen patients with PAR and 14 NARES patients were recruited for this 
      cross-sectional study. Fourteen healthy subjects were included as controls. The 
      concentrations of MCP-1, MCP-3, and RANTES in nasal secretions were measured 
      using enzyme-linked immunosorbent assay (ELISA). Eosinophil counts were performed 
      by percentage of differential granulocyte counts during cytological examination 
      of scraped nasal mucosa obtained from the inferior turbinate. Therefore, we 
      scored rhinitis patients according to nasal symptom score. RESULTS: We found 
      significantly higher concentrations of MCP-1 (p < 0.0001), MCP-3 (p = 0.018), and 
      RANTES (p < 0.0001) in nasal fluid of NARES patients compared to patients with 
      PAR. In PAR patients, we found positive correlation between RANTES levels and 
      nasal symptom score and eosinophil counts. In patients with NARES, the 
      concentrations of MCP-1 and RANTES were associated with nasal symptom score and 
      percentage of eosinophils. CONCLUSION: NARES is characterized by higher degree of 
      eosinophilic inflammation than PAR. RANTES correlates well with the level of 
      eosinophilic inflammation in both diseases. The measurement of chemokine levels 
      in nasal secretions could be useful in evaluating the degree of chronic nasal 
      inflammation.
CI  - (c) 2015 ARS-AAOA, LLC.
FAU - Peric, Aleksandar
AU  - Peric A
AD  - Department of Otorhinolaryngology, Rhinology Unit, Faculty of Medicine, Military 
      Medical Academy, Belgrade, Serbia.
FAU - Sotirovic, Jelena
AU  - Sotirovic J
AD  - Department of Otorhinolaryngology, Rhinology Unit, Faculty of Medicine, Military 
      Medical Academy, Belgrade, Serbia.
FAU - Spadijer-Mirkovic, Cveta
AU  - Spadijer-Mirkovic C
AD  - Department of Otorhinolaryngology, Rhinology Unit, Faculty of Medicine, Military 
      Medical Academy, Belgrade, Serbia.
FAU - Matkovic-Jozin, Svjetlana
AU  - Matkovic-Jozin S
AD  - Department of Otorhinolaryngology, Stavanger University Hospital, Stavanger, 
      Norway.
FAU - Peric, Aneta V
AU  - Peric AV
AD  - Institute for Pharmacy, Faculty of Medicine, Military Medical Academy, Belgrade, 
      Serbia.
FAU - Vojvodic, Danilo
AU  - Vojvodic D
AD  - Institute for Medical Research, Division of Clinical and Experimental Immunology, 
      Faculty of Medicine, Military Medical Academy, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20151217
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL5 protein, human)
RN  - 0 (CCL7 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokine CCL7)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/*metabolism
MH  - Chemokine CCL5/*metabolism
MH  - Chemokine CCL7/metabolism
MH  - Eosinophilia/*metabolism
MH  - Female
MH  - Humans
MH  - Hypersensitivity/diagnosis/metabolism
MH  - Male
MH  - Middle Aged
MH  - Nasal Mucosa/*metabolism
MH  - Rhinitis/*metabolism
MH  - Skin Tests
OTO - NOTNLM
OT  - MCP-1
OT  - MCP-3
OT  - RANTES
OT  - chemokines
OT  - eosinophils
OT  - nasal secretions
OT  - nonallergic rhinitis with eosinophilia syndrome
OT  - perennial allergic rhinitis
EDAT- 2015/12/19 06:00
MHDA- 2016/12/31 06:00
CRDT- 2015/12/19 06:00
PHST- 2015/07/11 00:00 [received]
PHST- 2015/10/20 00:00 [revised]
PHST- 2015/10/24 00:00 [accepted]
PHST- 2015/12/19 06:00 [entrez]
PHST- 2015/12/19 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
AID - 10.1002/alr.21684 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2016 Apr;6(4):392-7. doi: 10.1002/alr.21684. Epub 2015 
      Dec 17.