PMID- 26679817
OWN - NLM
STAT- MEDLINE
DCOM- 20160901
LR  - 20181202
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 103
DP  - 2015 Dec
TI  - Concurrent vaccination of pigs with type 1 and type 2 porcine reproductive and 
      respiratory syndrome virus (PRRSV) protects against type 1 PRRSV but not against 
      type 2 PRRSV on dually challenged pigs.
PG  - 193-200
LID - S0034-5288(15)30085-0 [pii]
LID - 10.1016/j.rvsc.2015.10.011 [doi]
AB  - The objective of the present study was to evaluate the effect of concurrent 
      vaccination of pigs with both type 1 and type 2 porcine reproductive and 
      respiratory syndrome virus (PRRSV) vaccine against heterologous dual challenge of 
      both genotypes and compare with single vaccination of pigs against heterologous 
      single challenge of both genotypes. Pigs were administered both type 1 and type 2 
      PRRSV vaccine concurrently into separate anatomical sites at 28 days of age and 
      inoculated intranasally with both genotypes at 63 days of age. Neutralizing 
      antibodies (NA) were not detected in any pigs in any group (NA titer <2 log2) 
      throughout the experiment. In addition, concurrent vaccination of pigs with two 
      PRRSV genotypes had significantly lower numbers of type 1 and type 2 
      PRRSV-specific interferon-gamma secreting cells (IFN-gamma-SC) compared to vaccination of 
      pigs with type 1 or type 2 PRRSV only. Despite the decreased induction of type 1 
      PRRSV-specific IFN-gamma-SC, concurrent vaccination is still able to reduce type 1 
      PRRSV viremia whereas the decreased induction of type 2 PRRSV-specific IFN-gamma-SC 
      by concurrent vaccination correlates with lack of reduction of type 2 PRRSV 
      viremia after dual challenge. The results of this study demonstrated that 
      concurrent vaccination of pigs with two PRRSV genotypes is able to reduce the 
      levels of type 1 PRRSV viremia and lung lesions but not able to reduce the levels 
      of type 2 PRRSV viremia and lung lesions.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Park, Changhoon
AU  - Park C
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Choi, Kyuhyung
AU  - Choi K
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Kang, Ikjae-
AU  - Kang I
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul 151-742, Republic of Korea. Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151028
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Viral Vaccines)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/blood
MH  - Antibodies, Viral/*blood
MH  - Interferon-gamma/immunology
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/*prevention & 
      control/virology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
MH  - Vaccination/methods/*veterinary
MH  - Viral Vaccines/*immunology
MH  - Viremia/veterinary/virology
OTO - NOTNLM
OT  - Concurrent vaccination
OT  - Interference
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Porcine reproductive and respiratory syndrome virus vaccine
EDAT- 2015/12/19 06:00
MHDA- 2016/09/02 06:00
CRDT- 2015/12/19 06:00
PHST- 2015/05/22 00:00 [received]
PHST- 2015/10/19 00:00 [revised]
PHST- 2015/10/25 00:00 [accepted]
PHST- 2015/12/19 06:00 [entrez]
PHST- 2015/12/19 06:00 [pubmed]
PHST- 2016/09/02 06:00 [medline]
AID - S0034-5288(15)30085-0 [pii]
AID - 10.1016/j.rvsc.2015.10.011 [doi]
PST - ppublish
SO  - Res Vet Sci. 2015 Dec;103:193-200. doi: 10.1016/j.rvsc.2015.10.011. Epub 2015 Oct 
      28.