PMID- 26681031
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20151218
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Dec 14
TI  - Meta-analysis of the association between the rs7903146 polymorphism at the TCF7L2 
      locus and type 2 diabetes mellitus susceptibility.
PG  - 16856-62
LID - 10.4238/2015.December.14.12 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and 
      environmental factors. T2DM has been associated with specific polymorphisms in 
      the TCF7L2 gene. This study evaluates the relationship between the rs7903146 
      locus polymorphism of the TCF7L2 gene and T2DM susceptibility through 
      meta-analysis; the overall aim is to provide a basis for evidence-based medicinal 
      treatment of T2DM. Cohort and case-control studies from Medline, PubMed, EMBASE, 
      CBM, CNKI, and academic conferences/dissertations that examined the correlation 
      between T2DM and rs7903146 polymorphisms were evaluated. We determined whether 
      the TCF7L2 rs7903146 locus was associated with T2DM susceptibility by comparing 
      alleles and genotypes. The Stata 11.0 software was applied for meta-analysis, and 
      a random-effects model was adopted for heterogeneity testing and odds ratio (OR) 
      calculation. A fixed-effect model was used for quantitative analysis of the 
      heterogeneity between different studies, and for calculating the percentage of 
      variability I(2). A total of 10 studies related to the rs7903146 loci and T2DM 
      susceptibility were enrolled; this included 3404 cases of T2DM patients and 6473 
      control cases. Meta-analysis showed that the T allele of rs7903146 was 
      significantly correlated with the risk of T2DM, with both a dominant fixed-effect 
      model (OR = 1.653, 95%CI = 1.416-1.653) and a co-dominant-fixed effect model (OR 
      = 1.525, 95%CI = 1.350-1.723). Meta-analysis revealed that the T allele of 
      rs7903146 was also correlated with T2DM susceptibility.
FAU - Liu, X H
AU  - Liu XH
AD  - Chengdu University of TCM, Chengdu, Sichuan, China.
AD  - Affiliated Hospital of Chengdu University of TCM, Chengdu, China.
FAU - Xie, C G
AU  - Xie CG
AD  - Affiliated Hospital of Chengdu University of TCM, Chengdu, China.
FAU - An, Y
AU  - An Y
AD  - Department of Urology, Sichuan Academy of Medical Sciences and Sichuan Provincial 
      People's Hospital, Chengdu, Sichuan, China.
FAU - Zhang, X X
AU  - Zhang XX
AD  - Affiliated Hospital of Chengdu University of TCM, Chengdu, China.
FAU - Wu, W B
AU  - Wu WB
AD  - Affiliated Hospital of Chengdu University of TCM, Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20151214
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - *Alleles
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Frequency
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Transcription Factor 7-Like 2 Protein/*genetics
EDAT- 2015/12/19 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/12/19 06:00
PHST- 2015/12/19 06:00 [entrez]
PHST- 2015/12/19 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - gmr6246 [pii]
AID - 10.4238/2015.December.14.12 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Dec 14;14(4):16856-62. doi: 10.4238/2015.December.14.12.