PMID- 26681054
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20151218
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Dec 16
TI  - Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis.
PG  - 17068-78
LID - 10.4238/2015.December.16.7 [doi]
AB  - Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is 
      significantly involved in cancer progression. Recent studies yielded conflicting 
      results regarding the association between serum MMP-3 and ankylosing spondylitis 
      (AS). To clarify this correlation, we performed a meta-analysis. Potential 
      relevant studies were identified by searching the following databases: PubMed, 
      Embase, CINAHL, Science Citation Index database, the Cochrane Library, Current 
      Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu 
      Journal. Data from eligible studies were extracted and included into the 
      meta-analysis using a random-effect model. Standardized mean differences (SMDs) 
      and 95% confidence intervals (CIs) were used to assess the association between 
      serum MMP-3 levels and AS. Thirteen case-control studies, including 707 AS cases 
      and 442 healthy controls, were selected for the meta-analysis. The results 
      indicate a significantly higher serum MMP-3 level in patients with AS than that 
      in the controls (cases vs controls: SMD = 1.31, 95%CI = 0.84-1.78, P < 0.001). 
      Ethnicity-subgroup analysis indicated a higher MMP-3 level in Asian and Caucasian 
      patients with AS (all P < 0.05). This meta-analysis indicates that increased 
      serum MMP-3 level correlates with the development of AS, suggesting that MMP-3 
      may present a clinical value in reflecting the progression of AS. Further larger 
      sample size studies are warranted.
FAU - Gao, J W
AU  - Gao JW
AD  - Department of Spine Surgery, the First People's Hospital of Jining City, Jining, 
      China.
FAU - Zhang, K F
AU  - Zhang KF
AD  - Department of Spine Surgery, the First People's Hospital of Jining City, Jining, 
      China.
FAU - Lu, J S
AU  - Lu JS
AD  - Department of Spine Surgery, the First People's Hospital of Jining City, Jining, 
      China.
FAU - Su, T
AU  - Su T
AD  - Department of Pediatric Surgery, the First People's Hospital of Jining City, 
      Jining, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20151216
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Disease Susceptibility
MH  - Humans
MH  - Matrix Metalloproteinase 3/*blood
MH  - Publication Bias
MH  - Risk
MH  - Spondylitis, Ankylosing/*blood
EDAT- 2015/12/19 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/12/19 06:00
PHST- 2015/12/19 06:00 [entrez]
PHST- 2015/12/19 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - gmr6559 [pii]
AID - 10.4238/2015.December.16.7 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Dec 16;14(4):17068-78. doi: 10.4238/2015.December.16.7.