PMID- 26681056
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20151218
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Dec 16
TI  - Regulating effect of MMP-9 and TIMP-1 in pituitary adenoma invasion.
PG  - 17091-8
LID - 10.4238/2015.December.16.9 [doi]
AB  - Pituitary adenomas can cause endocrine disorder and organ damage, with some 
      aggressive ones leading to a high postoperative recurrence rate. The occurrence 
      and development of these type of tumors is closely related with matrix 
      metalloproteinases (MMPs) and endogenous specific tissue inhibitor of MMPs 
      (TIMPs). In this study, the relationship between pituitary adenoma invasion and 
      the changes in MMP-8 and TIMP-1 expressions is analyzed. Specimens from sixty 
      patients with pituitary adenoma were collected in our hospital after surgery, 
      including thirty cases of invasive pituitary adenomas and thirty cases of 
      noninvasive pituitary adenomas. Western blotting and real-time PCR were used to 
      detect MMP-8/TIMP-1 protein and mRNA levels, respectively, in the two types of 
      pituitary adenomas, while ELISA was used to detect both compounds' levels in the 
      patient's serum. Compared with noninvasive pituitary adenomas, MMP-8 was 
      significantly overexpressed in invasive pituitary adenomas, while TIMP-1 was 
      obviously lower (P < 0.05 for both). Moreover, MMP-8 mRNA expression in invasive 
      pituitary adenomas was significantly higher than in noninvasive pituitary 
      adenomas, while TIMP-1 mRNA expression was markedly lower (P < 0.05 for both). 
      Finally, MMP-8 expression in the serum is upregulated in patients with invasive 
      pituitary adenomas relative to the noninvasive ones, and the expression of TIMP-1 
      significantly reduced (P < 0.05 for both). These results show that increased 
      MMP-8 and decreased TIMP-1 expressions are closely related to the invasive 
      pituitary adenoma, and can be helpful for the evaluation.
FAU - Mao, J H
AU  - Mao JH
AD  - Department of Neurosurgery, Harrison International Peace Hospital attached to 
      Hebei Medical University, Hengshui, Hebei, China.
FAU - Guo, H
AU  - Guo H
AD  - Department of Neurosurgery, Harrison International Peace Hospital attached to 
      Hebei Medical University, Hengshui, Hebei, China.
FAU - Si, N
AU  - Si N
AD  - Department of Anesthesiology, Harrison International Peace Hospital attached to 
      Hebei Medical University, Hengshui, Hebei, China.
FAU - Qiu, L
AU  - Qiu L
AD  - Department of Pathology, Harrison International Peace Hospital attached to Hebei 
      Medical University, Hengshui, Hebei, China.
FAU - Guo, L F
AU  - Guo LF
AD  - Department of Laboratory Medicine, Harrison International Peace Hospital attached 
      to Hebei Medical University, Hengshui, Hebei, China.
FAU - Sun, Z S
AU  - Sun ZS
AD  - Department of Neurosurgery, Harrison International Peace Hospital attached to 
      Hebei Medical University, Hengshui, Hebei, China.
FAU - Xiang, Y
AU  - Xiang Y
AD  - Department of Neurosurgery, Harrison International Peace Hospital attached to 
      Hebei Medical University, Hengshui, Hebei, China.
FAU - Yang, X H
AU  - Yang XH
AD  - Department of Neurosurgery, Harrison International Peace Hospital attached to 
      Hebei Medical University, Hengshui, Hebei, China.
FAU - Zhao, W G
AU  - Zhao WG
AD  - Department of Neurosurgery, Harrison International Peace Hospital attached to 
      Hebei Medical University, Hengshui, Hebei, China.
FAU - Zhang, W C
AU  - Zhang WC
AD  - Department of Neurosurgery, Harrison International Peace Hospital attached to 
      Hebei Medical University, Hengshui, Hebei, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151216
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Messenger)
RN  - 0 (TIMP1 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adenoma/*genetics/metabolism/*pathology
MH  - Adult
MH  - Biomarkers
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 9/blood/*genetics/metabolism
MH  - Middle Aged
MH  - Pituitary Neoplasms/*genetics/metabolism/*pathology
MH  - RNA, Messenger/genetics/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-1/blood/*genetics/metabolism
MH  - Tumor Burden
MH  - Young Adult
EDAT- 2015/12/19 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/12/19 06:00
PHST- 2015/12/19 06:00 [entrez]
PHST- 2015/12/19 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - gmr6770 [pii]
AID - 10.4238/2015.December.16.9 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Dec 16;14(4):17091-8. doi: 10.4238/2015.December.16.9.