PMID- 26681781
OWN - NLM
STAT- MEDLINE
DCOM- 20160517
LR  - 20181113
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Print)
IS  - 0031-4005 (Linking)
VI  - 137
IP  - 1
DP  - 2016 Jan
TI  - Fatal Myocarditis Associated With HHV-6 Following Immunosuppression in Two 
      Children.
LID - 10.1542/peds.2015-1352 [doi]
LID - e20151352
AB  - Fatal myocarditis is a rare complication in immunosuppressed children. Recent 
      reports have linked human herpesvirus 6 (HHV-6) infection, typically a benign 
      infection in childhood, with myocarditis. HHV-6 can reactivate during periods of 
      immunosuppression. Here, we report 2 cases in which children were 
      immunosuppressed, one for treatment of Evans syndrome and the other post 
      hematopoietic stem cell transplantation, who developed rapid and fatal 
      HHV-6-associated myocarditis. These cases suggest that HHV-6 infection should be 
      considered as an etiology of myocarditis in immunosuppressed patients regardless 
      of correlating blood levels. Early treatment of HHV-6 in patients with 
      myocarditis could improve morbidity and mortality.
CI  - Copyright (c) 2016 by the American Academy of Pediatrics.
FAU - Stefanski, Heather E
AU  - Stefanski HE
AD  - Divsion of Pediatric Blood and Marrow Transplant, University of Minnesota, 
      Minneapolis, Minnesota; and.
FAU - Thibert, Kathryn A
AU  - Thibert KA
AD  - Divsion of Pediatric Blood and Marrow Transplant, University of Minnesota, 
      Minneapolis, Minnesota; and.
FAU - Pritchett, Joshua
AU  - Pritchett J
AD  - Divsion of Pediatric Blood and Marrow Transplant, University of Minnesota, 
      Minneapolis, Minnesota; and.
FAU - Prusty, Bhupesh K
AU  - Prusty BK
AD  - Biocenter, Chair of Microbiology, University of Wurzburg, Wurzburg, Germany.
FAU - Wagner, John E
AU  - Wagner JE
AD  - Divsion of Pediatric Blood and Marrow Transplant, University of Minnesota, 
      Minneapolis, Minnesota; and.
FAU - Lund, Troy C
AU  - Lund TC
AD  - Divsion of Pediatric Blood and Marrow Transplant, University of Minnesota, 
      Minneapolis, Minnesota; and lundx072@umn.edu.
LA  - eng
GR  - K08 HL108998/HL/NHLBI NIH HHS/United States
GR  - K12 HD068322/HD/NICHD NIH HHS/United States
GR  - K08HL108998/HL/NHLBI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151217
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Adolescent
MH  - Child, Preschool
MH  - Fatal Outcome
MH  - Female
MH  - Herpesviridae Infections/*complications
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Immunocompromised Host
MH  - Male
MH  - Myocarditis/*complications
PMC - PMC5545791
MID - NIHMS870913
COIS- POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential 
      conflicts of interest to disclose. FINANCIAL DISCLOSURE: The authors have 
      indicated they have no financial relationships relevant to this article to 
      disclose.
EDAT- 2015/12/19 06:00
MHDA- 2016/05/18 06:00
PMCR- 2017/01/01
CRDT- 2015/12/19 06:00
PHST- 2015/09/15 00:00 [accepted]
PHST- 2015/12/19 06:00 [entrez]
PHST- 2015/12/19 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - peds.2015-1352 [pii]
AID - peds.2015-1352.137.1.e20151352 [pii]
AID - 10.1542/peds.2015-1352 [doi]
PST - ppublish
SO  - Pediatrics. 2016 Jan;137(1):e20151352. doi: 10.1542/peds.2015-1352. Epub 2015 Dec 
      17.