PMID- 26681831
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151218
LR  - 20181113
IS  - 0860-021X (Print)
IS  - 2083-1862 (Electronic)
IS  - 0860-021X (Linking)
VI  - 32
IP  - 4
DP  - 2015 Nov
TI  - Long-term treadmill exercise improves spatial memory of male APPswe/PS1dE9 mice 
      by regulation of BDNF expression and microglia activation.
PG  - 295-300
LID - 10.5604/20831862.1163692 [doi]
AB  - Increasing evidence suggests that physical activity could delay or attenuate the 
      symptoms of Alzheimer's disease (AD). But the underlying mechanisms are still not 
      fully understood. To investigate the effect of long-term treadmill exercise on 
      the spatial memory of AD mice and the possible role of beta-amyloid, brain-derived 
      neurotrophic factor (BDNF) and microglia in the effect, male APPswe/PS1dE9 AD 
      mice aged 4 months were subjected to treadmill exercise for 5 months with 6 
      sessions per week and gradually increased load. A Morris water maze was used to 
      evaluate the spatial memory. Expression levels of beta-amyloid, BDNF and Iba-1 (a 
      microglia marker) in brain tissue were detected by immunohistochemistry. 
      Sedentary AD mice and wildtype C57BL/6J mice served as controls. The results 
      showed that 5-month treadmill exercise significantly decreased the escape 
      latencies (P < 0.01 on the 4th day) and improved the spatial memory of the AD 
      mice in the water maze test. Meanwhile, treadmill exercise significantly 
      increased the number of BDNF-positive cells and decreased the ratios of activated 
      microglia in both the cerebral cortex and the hippocampus. However, treadmill 
      exercise did not significantly alleviate the accumulation of beta-amyloid in either 
      the cerebral cortex or the hippocampus of the AD mice (P > 0.05). The study 
      suggested that long-term treadmill exercise could improve the spatial memory of 
      the male APPswe/PS1dE9 AD mice. The increase in BDNF-positive cells and decrease 
      in activated microglia might underpin the beneficial effect.
FAU - Xiong, J Y
AU  - Xiong JY
AD  - School of Physical Education, Lingnan Normal University, Zhanjiang 524048, China 
      ; Equal contribution.
FAU - Li, S C
AU  - Li SC
AD  - School of Physical Education, Lingnan Normal University, Zhanjiang 524048, China 
      ; Equal contribution.
FAU - Sun, Y X
AU  - Sun YX
AD  - Library of Mudanjiang Medical University, Mudanjiang 157011, China ; Equal 
      contribution.
FAU - Zhang, X S
AU  - Zhang XS
AD  - School of Physical Education, Lingnan Normal University, Zhanjiang 524048, China 
      ; Equal contribution.
FAU - Dong, Z Z
AU  - Dong ZZ
AD  - The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325200, 
      China.
FAU - Zhong, P
AU  - Zhong P
AD  - Laboratory of Physiological Science, Guangdong Medical University, Dongguan 
      523808, China.
FAU - Sun, X R
AU  - Sun XR
AD  - Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong 
      Medical University, Dongguan 523808, China ; Institute of Aging Research, 
      Dongguan Scientific Center, Guangdong Medical University, Dongguan 523808, China.
LA  - eng
PT  - Journal Article
DEP - 20150804
PL  - Poland
TA  - Biol Sport
JT  - Biology of sport
JID - 8700872
PMC - PMC4672160
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - brain-derived neurotrophic
OT  - exercise
OT  - factor
OT  - mice
OT  - microglia
EDAT- 2015/12/19 06:00
MHDA- 2015/12/19 06:01
PMCR- 2015/12/01
CRDT- 2015/12/19 06:00
PHST- 2014/06/19 00:00 [received]
PHST- 2015/01/30 00:00 [revised]
PHST- 2015/05/22 00:00 [accepted]
PHST- 2015/12/19 06:00 [entrez]
PHST- 2015/12/19 06:00 [pubmed]
PHST- 2015/12/19 06:01 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 1163692 [pii]
AID - 10.5604/20831862.1163692 [doi]
PST - ppublish
SO  - Biol Sport. 2015 Nov;32(4):295-300. doi: 10.5604/20831862.1163692. Epub 2015 Aug 
      4.