PMID- 26682011
OWN - NLM
STAT- MEDLINE
DCOM- 20160908
LR  - 20181113
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2016
DP  - 2016
TI  - High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in 
      Ovarian and Prostate Cancer.
PG  - 5845061
LID - 10.1155/2016/5845061 [doi]
LID - 5845061
AB  - Cancer cells try to avoid the overproduction of reactive oxygen species by 
      metabolic rearrangements. These cells also develop specific strategies to 
      increase ROS resistance and to express the enzymatic activities necessary for ROS 
      detoxification. Oxidative stress produces DNA damage and also induces responses, 
      which could help the cell to restore the initial equilibrium. But if this is not 
      possible, oxidative stress finally activates signals that will lead to cell 
      death. High mobility group B (HMGB) proteins have been previously related to the 
      onset and progressions of cancers of different origins. The protein HMGB1 behaves 
      as a redox sensor and its structural changes, which are conditioned by the 
      oxidative environment, are associated with different functions of the protein. 
      This review describes recent advances in the role of human HMGB proteins and 
      other proteins interacting with them, in cancerous processes related to oxidative 
      stress, with special reference to ovarian and prostate cancer. Their 
      participation in the molecular mechanisms of resistance to cisplatin, a drug 
      commonly used in chemotherapy, is also revised.
FAU - Barreiro-Alonso, Aida
AU  - Barreiro-Alonso A
AD  - Center for Investigacions Cientificas Avanzadas (CICA), Department of Cellular 
      and Molecular Biology, Sciences Faculty, University of Coruna, 15071 A Coruna, 
      Spain ; Translational Cancer Research Group, A Coruna Biomedical Research 
      Institute (INIBIC), Carretera del Pasaje s/n, 15006 A Coruna, Spain.
FAU - Lamas-Maceiras, Monica
AU  - Lamas-Maceiras M
AD  - Center for Investigacions Cientificas Avanzadas (CICA), Department of Cellular 
      and Molecular Biology, Sciences Faculty, University of Coruna, 15071 A Coruna, 
      Spain ; Translational Cancer Research Group, A Coruna Biomedical Research 
      Institute (INIBIC), Carretera del Pasaje s/n, 15006 A Coruna, Spain.
FAU - Rodriguez-Belmonte, Esther
AU  - Rodriguez-Belmonte E
AD  - Center for Investigacions Cientificas Avanzadas (CICA), Department of Cellular 
      and Molecular Biology, Sciences Faculty, University of Coruna, 15071 A Coruna, 
      Spain ; Translational Cancer Research Group, A Coruna Biomedical Research 
      Institute (INIBIC), Carretera del Pasaje s/n, 15006 A Coruna, Spain.
FAU - Vizoso-Vazquez, Angel
AU  - Vizoso-Vazquez A
AD  - Center for Investigacions Cientificas Avanzadas (CICA), Department of Cellular 
      and Molecular Biology, Sciences Faculty, University of Coruna, 15071 A Coruna, 
      Spain ; Translational Cancer Research Group, A Coruna Biomedical Research 
      Institute (INIBIC), Carretera del Pasaje s/n, 15006 A Coruna, Spain.
FAU - Quindos, Maria
AU  - Quindos M
AD  - Translational Cancer Research Group, A Coruna Biomedical Research Institute 
      (INIBIC), Carretera del Pasaje s/n, 15006 A Coruna, Spain.
FAU - Cerdan, M Esperanza
AU  - Cerdan ME
AD  - Center for Investigacions Cientificas Avanzadas (CICA), Department of Cellular 
      and Molecular Biology, Sciences Faculty, University of Coruna, 15071 A Coruna, 
      Spain ; Translational Cancer Research Group, A Coruna Biomedical Research 
      Institute (INIBIC), Carretera del Pasaje s/n, 15006 A Coruna, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151123
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (HMGB Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Female
MH  - HMGB Proteins/*metabolism
MH  - Humans
MH  - Male
MH  - Neoplasm Proteins/*metabolism
MH  - Ovarian Neoplasms/*metabolism/pathology
MH  - Oxidation-Reduction
MH  - Prostatic Neoplasms/*metabolism/pathology
MH  - Reactive Oxygen Species/*metabolism
PMC - PMC4670870
EDAT- 2015/12/19 06:00
MHDA- 2016/09/09 06:00
PMCR- 2015/11/23
CRDT- 2015/12/19 06:00
PHST- 2015/06/02 00:00 [received]
PHST- 2015/07/27 00:00 [accepted]
PHST- 2015/12/19 06:00 [entrez]
PHST- 2015/12/19 06:00 [pubmed]
PHST- 2016/09/09 06:00 [medline]
PHST- 2015/11/23 00:00 [pmc-release]
AID - 10.1155/2016/5845061 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2016;2016:5845061. doi: 10.1155/2016/5845061. Epub 2015 Nov 
      23.