PMID- 26682049
OWN - NLM
STAT- MEDLINE
DCOM- 20160713
LR  - 20181202
IS  - 2047-2978 (Print)
IS  - 2047-2986 (Electronic)
IS  - 2047-2978 (Linking)
VI  - 5
IP  - 2
DP  - 2015 Dec
TI  - Burden of respiratory syncytial virus infections in China: Systematic review and 
      meta-analysis.
PG  - 020417
LID - 10.7189/jogh.05.020417 [doi]
LID - 020417
AB  - BACKGROUND: Respiratory syncytial virus (RSV) is the most important cause of 
      acute respiratory tract infection (ARTI) related morbidity and mortality 
      worldwide. However, the disease burden due to RSV has not been systematically 
      summarized in China. METHOD: A systematic search was performed in the Chinese 
      BioMedical Database (CBM), China National Knowledge Infrastructure (CNKI), 
      Wanfang database and PubMed to identify available published RSV studies in China. 
      RESULTS: A total of 489 641 patients with ARTIs from 135 studies were included in 
      the analysis. Among patients with ARTIs, RSV accounted for 18.7% (95% confidence 
      interval CI 17.1-20.5%). The prevalence of RSV was highest in infants (26.5%, 95% 
      CI 23.7-29.5%) and lowest in those aged >/=16 years (2.8%, 95% CI 1.3-6.1). A 
      higher prevalence of RSV was seen in inpatients (22%, 95% CI 19.9-24.2%) than in 
      outpatients (14%, 95% CI 9.6-19.9%). RSV type A accounted for 63.1% (95% CI 
      52.3-72.8%) of all RSV infections. RSV infections occurred mainly in winter and 
      spring. The most common clinical manifestations were cough, production of sputum, 
      wheezing and fever. CONCLUSION: RSV is the leading cause of viral ARTIs in China, 
      particularly in infants and young children. Our findings are valuable for guiding 
      the selection of appropriate therapies for ARTIs and implementation of preventive 
      measures against RSV infections. Our data further supports the development of a 
      successful RSV vaccine as a high priority.
FAU - Zhang, Yaowen
AU  - Zhang Y
AD  - Infection Management and Disease Prevention Department, China-Japan Friendship 
      Hospital, Beijing, China.
FAU - Yuan, Lichao
AU  - Yuan L
AD  - Department of Infectious Diseases, China-Japan Friendship Hospital, Beijing, 
      China.
FAU - Zhang, Yongming
AU  - Zhang Y
AD  - Department of Respiratory Diseases, China-Japan Friendship Hospital, Beijing, 
      China.
FAU - Zhang, Xiuping
AU  - Zhang X
AD  - China-Japan Friendship Clinical College, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Zheng, Minghuan
AU  - Zheng M
AD  - Sanofi Pasteur, Beijing, China.
FAU - Kyaw, Moe H
AU  - Kyaw MH
AD  - Sanofi Pasteur, Swiftwater, PA, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - Scotland
TA  - J Glob Health
JT  - Journal of global health
JID - 101578780
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - *Hospitalization
MH  - Humans
MH  - Infant
MH  - Prevalence
MH  - Respiratory Syncytial Virus Infections/*epidemiology
MH  - Respiratory Syncytial Virus, Human/isolation & purification
MH  - Respiratory Tract Infections/epidemiology/*virology
MH  - Seasons
PMC - PMC4676581
EDAT- 2015/12/19 06:00
MHDA- 2016/07/14 06:00
PMCR- 2015/12/02
CRDT- 2015/12/19 06:00
PHST- 2015/12/19 06:00 [entrez]
PHST- 2015/12/19 06:00 [pubmed]
PHST- 2016/07/14 06:00 [medline]
PHST- 2015/12/02 00:00 [pmc-release]
AID - jogh-05-020417 [pii]
AID - 10.7189/jogh.05.020417 [doi]
PST - ppublish
SO  - J Glob Health. 2015 Dec;5(2):020417. doi: 10.7189/jogh.05.020417.