PMID- 26682524
OWN - NLM
STAT- MEDLINE
DCOM- 20161017
LR  - 20220330
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 70
IP  - 3
DP  - 2016 Mar
TI  - Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, 
      GluN2A-subunits and BDNF proteins in the adult rat hippocampus.
PG  - 121-4
LID - 10.1002/syn.21880 [doi]
AB  - Compelling data suggest that perturbations in microbial colonization of the gut 
      in early-life, influences neurodevelopment and adult brain function. If this is 
      the case, then ensuring the growth of beneficial bacteria at an early age will 
      lead to optimal brain development and maturation. We have tested whether feeding 
      neonatal rats daily (from post-natal days 3-21) with a galacto-oligosaccharide 
      prebiotic (Bimuno(R), BGOS) or a control solution, alters the levels of hippocampal 
      N-Methyl-D-Aspartate receptor (NMDAR) subunits (GluN1, GluN2A, GluN2B), synaptic 
      proteins (synaptophysin, MAP2, and GAP43) and brain-derived-neurotrophic factor 
      (BDNF), at post-natal days 22 and 56. The administration of BGOS significantly 
      elevated GluN2A subunits, synaptophysin and BDNF in the hippocampus of 22 day old 
      rats. The effect was also observed on day 56 (26 days after the feeding ceased). 
      The levels of all other proteins (GluN1, GluN2B, MAP2, GAP43) remained unaltered. 
      Increased GluN2A, synaptophysin, BDNF, but not MAP2, may suggest that neonatal 
      BGOS feeding alters neurotransmission rather than synaptic architecture. Although 
      the functional consequences of our findings require further investigation, the 
      current study confirms that the manipulation of gut bacteria in early-life, has 
      central effects that persist until at least young adulthood.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Williams, Sarah
AU  - Williams S
AD  - Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
FAU - Chen, Li
AU  - Chen L
AD  - Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
FAU - Savignac, Helene M
AU  - Savignac HM
AD  - Clasado Research Services Ltd, Reading, RG6 6BZ, United Kingdom.
FAU - Tzortzis, George
AU  - Tzortzis G
AD  - Clasado Research Services Ltd, Reading, RG6 6BZ, United Kingdom.
FAU - Anthony, Daniel C
AU  - Anthony DC
AD  - Department of Pharmacology, University of Oxford, Oxford, OX1 3QT, United 
      Kingdom.
FAU - Burnet, Philip W J
AU  - Burnet PW
AD  - Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20160109
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GAP-43 Protein)
RN  - 0 (MAP2 protein, rat)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (NMDA receptor A1)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Prebiotics)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Synaptophysin)
RN  - 0 (Syp protein, rat)
RN  - VH92ICR8HX (N-methyl D-aspartate receptor subtype 2A)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Animals, Newborn
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - *Dietary Supplements
MH  - Female
MH  - GAP-43 Protein/metabolism
MH  - Hippocampus/growth & development/*metabolism
MH  - Male
MH  - Microtubule-Associated Proteins/metabolism
MH  - Prebiotics/*administration & dosage
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Synaptophysin/*metabolism
OTO - NOTNLM
OT  - BGOS
OT  - glutamate
OT  - neurodevelopment
EDAT- 2015/12/20 06:00
MHDA- 2016/10/19 06:00
CRDT- 2015/12/20 06:00
PHST- 2015/07/22 00:00 [received]
PHST- 2015/12/11 00:00 [revised]
PHST- 2015/12/14 00:00 [accepted]
PHST- 2015/12/20 06:00 [entrez]
PHST- 2015/12/20 06:00 [pubmed]
PHST- 2016/10/19 06:00 [medline]
AID - 10.1002/syn.21880 [doi]
PST - ppublish
SO  - Synapse. 2016 Mar;70(3):121-4. doi: 10.1002/syn.21880. Epub 2016 Jan 9.