PMID- 26687309
OWN - NLM
STAT- MEDLINE
DCOM- 20160203
LR  - 20181202
IS  - 1833-3516 (Print)
IS  - 1833-3516 (Linking)
VI  - 45
IP  - 4
DP  - 2015 Dec
TI  - Economic outcomes in clinical studies assessing hyperbaric oxygen in the 
      treatment of acute and chronic wounds.
PG  - 228-34
AB  - INTRODUCTION: Hyperbaric oxygen treatment (HBOT) is used to treat acute and 
      chronic wounds. This systematic review was conducted to summarise and evaluate 
      existing evidence on the costs associated with HBOT in the treatment of wounds. 
      METHODS: We searched multiple electronic databases in March 2015 for cohort 
      studies and randomised clinical trials (RCTs) that reported on the clinical 
      effectiveness and treatment costs of HBOT in the treatment of acute or chronic 
      wounds. RESULTS: One RCT and three cohort studies reported on economic as well as 
      clinical outcomes. These studies comprised different disorders (ischaemic 
      diabetic foot ulcers, thermal burns, Fournier's gangrene and necrotising soft 
      tissue infections) and employed different clinical and economic outcome measures. 
      Only the RCT had a good methodological quality. Three of the included studies 
      reported that their primary clinical outcomes (wound healing, hospital stay, 
      complications) improved in the HBOT group. The effects of HBOT on costs were 
      variable. CONCLUSIONS: Currently, there is little direct evidence on the 
      cost-effectiveness of HBOT in the treatment of acute and chronic wounds. Although 
      there is some evidence suggesting effectiveness of HBOT, further studies should 
      include economic outcomes in order to make recommendations on the 
      cost-effectiveness of applying HBOT in wound care.
FAU - Santema, Trientje B
AU  - Santema TB
AD  - Department of Surgery, room G4-132, Academic Medical Center, P O Box 22660, 1100 
      DD Amsterdam, The Netherlands, Phone: +31-(0)20-566-3405, Fax: 
      +31-(0)20-566-6569, E-mail: t.b.santema@amc.uva.nl.
FAU - Stoekenbroek, Robert M
AU  - Stoekenbroek RM
AD  - Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
FAU - van Steekelenburg, Koen C
AU  - van Steekelenburg KC
AD  - Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
FAU - van Hulst, Rob A
AU  - van Hulst RA
AD  - Department of Hyperbaric Medicine, Academic Medical Center, Amsterdam, The 
      Netherlands.
FAU - Koelemay, Mark Jw
AU  - Koelemay MJ
AD  - Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
FAU - Ubbink, Dirk T
AU  - Ubbink DT
AD  - Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
SB  - IM
CIN - Diving Hyperb Med. 2015 Dec;45(4):218. PMID: 26687307
MH  - Acute Disease
MH  - Burns/*therapy
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Cost-Benefit Analysis
MH  - Diabetic Foot/*therapy
MH  - Fournier Gangrene/*therapy
MH  - Hospital Charges
MH  - Humans
MH  - Hyperbaric Oxygenation/*economics
MH  - Observational Studies as Topic
MH  - Randomized Controlled Trials as Topic
MH  - Soft Tissue Infections/*therapy
MH  - Wound Healing
MH  - Wounds and Injuries/therapy
OTO - NOTNLM
OT  - Hyperbaric oxygen therapy
OT  - cost-effectiveness
OT  - outcome
OT  - systematic review
OT  - wounds
EDAT- 2015/12/22 06:00
MHDA- 2016/02/04 06:00
CRDT- 2015/12/22 06:00
PHST- 2015/11/10 00:00 [received]
PHST- 2015/11/22 00:00 [accepted]
PHST- 2015/12/22 06:00 [entrez]
PHST- 2015/12/22 06:00 [pubmed]
PHST- 2016/02/04 06:00 [medline]
PST - ppublish
SO  - Diving Hyperb Med. 2015 Dec;45(4):228-34.