PMID- 26688226
OWN - NLM
STAT- MEDLINE
DCOM- 20161019
LR  - 20220408
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1632
DP  - 2016 Feb 1
TI  - Decreased functional connectivity density in pain-related brain regions of female 
      migraine patients without aura.
PG  - 73-81
LID - S0006-8993(15)00946-4 [pii]
LID - 10.1016/j.brainres.2015.12.007 [doi]
AB  - Migraine is one of the most prevalent neurological disorders which is suggested 
      to be associated with dysfunctions of the central nervous system. The purpose of 
      the present study was to detect the altered functional connectivity architecture 
      in the large-scale network of the whole brain in migraine without aura (MWoA). 
      Meanwhile, the brain functional hubs which are targeted by MWoA could be 
      identified. A new voxel-based method named functional connectivity density (FCD) 
      mapping was applied to resting-state functional magnetic resonance imaging data 
      of 55 female MWoA patients and 44 age-matched female healthy controls (HC). 
      Comparing to HC, MWoA patients showed abnormal short-range FCD values in 
      bilateral hippocampus, bilateral insula, right amygdale, right anterior cingulate 
      cortex, bilateral putamen, bilateral caudate nucleus and the prefrontal cortex. 
      The results suggested decreased intraregional connectivity of these pain-related 
      brain regions in female MWoA. In addition, short-range FCD values in left 
      prefrontal cortex, putamen and caudate nucleus were significantly negatively 
      correlated with duration of disease in MWoA group, implying the repeated migraine 
      attacks over time may consistently affect the resting-state functional 
      connectivity architecture of these brain hubs. Our findings revealed the 
      dysfunction of brain hubs in female MWoA, and suggested the left prefrontal 
      cortex, putamen and caudate nucleus served as sensitive neuroimaging markers for 
      reflecting the disease duration of female MWoA. This may provide us new insights 
      into the changes in the organization of the large-scale brain network in MWoA.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Gao, Qing
AU  - Gao Q
AD  - School of Mathematical Sciences, University of Electronic Science and Technology 
      of China, Chengdu 610054, China. Electronic address: gaoqing@uestc.edu.cn.
FAU - Xu, Fei
AU  - Xu F
AD  - School of Mathematical Sciences, University of Electronic Science and Technology 
      of China, Chengdu 610054, China.
FAU - Jiang, Cui
AU  - Jiang C
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu 610075, China.
FAU - Chen, Zhifeng
AU  - Chen Z
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu 610075, China.
FAU - Chen, Huafu
AU  - Chen H
AD  - Key Laboratory for Neuroinformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 610054, China.
FAU - Liao, Huaqiang
AU  - Liao H
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu 610075, China.
FAU - Zhao, Ling
AU  - Zhao L
AD  - Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu 610075, China. Electronic address: ling94@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151210
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/metabolism
MH  - Brain Mapping/methods
MH  - Caudate Nucleus/*metabolism
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Middle Aged
MH  - Migraine without Aura/diagnosis/*metabolism
MH  - Nerve Net/*metabolism
MH  - Pain/diagnosis/*metabolism
MH  - Prefrontal Cortex/*metabolism
MH  - Putamen/*metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Brain hubs
OT  - Functional connectivity density
OT  - Functional magnetic resonance imaging
OT  - Migraine without aura
OT  - Resting-state
EDAT- 2015/12/22 06:00
MHDA- 2016/11/12 06:00
CRDT- 2015/12/22 06:00
PHST- 2015/07/10 00:00 [received]
PHST- 2015/11/05 00:00 [revised]
PHST- 2015/12/02 00:00 [accepted]
PHST- 2015/12/22 06:00 [entrez]
PHST- 2015/12/22 06:00 [pubmed]
PHST- 2016/11/12 06:00 [medline]
AID - S0006-8993(15)00946-4 [pii]
AID - 10.1016/j.brainres.2015.12.007 [doi]
PST - ppublish
SO  - Brain Res. 2016 Feb 1;1632:73-81. doi: 10.1016/j.brainres.2015.12.007. Epub 2015 
      Dec 10.