PMID- 26692322
OWN - NLM
STAT- MEDLINE
DCOM- 20161021
LR  - 20221207
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 30
IP  - 3
DP  - 2016 Mar
TI  - Effect of Black Tea Consumption on Intracellular Cytokines, Regulatory T Cells 
      and Metabolic Biomarkers in Type 2 Diabetes Patients.
PG  - 454-62
LID - 10.1002/ptr.5548 [doi]
AB  - The present study was undertaken to evaluate the effects of black tea intake on 
      inflammatory cytokines and metabolic biomarkers in Type 2 diabetes mellitus 
      (T2DM). Thirty patients with T2DM were randomly assigned either to a High Intake 
      (HI) group, consuming three cups (600 mL) of black tea per day; and a Low Intake 
      (LI) group, administered 1 cup (200 mL) per day, each during a 12-week period. 
      Intracellular cytokine expression, regulatory T cells (Treg), glycemic and lipid 
      profiles were measured at baseline and following the tea intake period. Tea 
      consumption correlated with major effects measured in peripheral blood of 
      subjects that included significantly reduced glycated hemoglobin (HbA1c) levels, 
      along with increased regulatory T cells CD3+ CD4+ CD25+ FOXP3, CD3+ CD4+ IL-10+ 
      cells (an immunosuppressive phenotype), reduced (pro-inflammatory) CD3+ CD4+ 
      IL-17+ cells and reduced Th1-associated CD3+ CD4+ IFN-Upsilon+ cells. Tea consumption 
      was also observed to abolish the significance of an inverse correlation between 
      total serum cholesterol and representation of CD4+ IL-4+ T cells, which may 
      reflect protection against atopy-related oxidative stress. Outcomes of this study 
      describe both advantages and limitations to consumption of black tea as an aid to 
      sustained health maintenance by persons at-risk for TD2M and related 
      obesity-associated metabolic syndromes.
CI  - Copyright (c) 2015 John Wiley & Sons, Ltd.
FAU - Mahmoud, Fadia
AU  - Mahmoud F
AD  - Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, 
      Kuwait University, Kuwait.
FAU - Haines, David
AU  - Haines D
AD  - Department of Pharmacology, Faculty of Pharmacy, Debrecen University, Hungary.
AD  - Essential Biotherapeutics Sarl, Rte. de la Vallee 26, 1874, Champery, 
      Switzerland.
FAU - Al-Ozairi, Ebaa
AU  - Al-Ozairi E
AD  - Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.
FAU - Dashti, Ali
AU  - Dashti A
AD  - Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, 
      Kuwait University, Kuwait.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20151221
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Interleukins)
RN  - 0 (Plant Extracts)
RN  - 0 (Tea)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Blood Glucose/metabolism
MH  - *Camellia sinensis
MH  - Diabetes Mellitus, Type 2/diet therapy/*metabolism
MH  - Female
MH  - Flow Cytometry
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Hypoglycemic Agents/pharmacology/therapeutic use
MH  - Interleukins/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - T-Lymphocytes, Regulatory/*metabolism
MH  - *Tea
OTO - NOTNLM
OT  - Treg cells
OT  - black tea
OT  - cytokines
OT  - diabetes
OT  - metabolic biomarkers
EDAT- 2015/12/23 06:00
MHDA- 2016/10/22 06:00
CRDT- 2015/12/23 06:00
PHST- 2015/07/26 00:00 [received]
PHST- 2015/11/24 00:00 [revised]
PHST- 2015/11/24 00:00 [accepted]
PHST- 2015/12/23 06:00 [entrez]
PHST- 2015/12/23 06:00 [pubmed]
PHST- 2016/10/22 06:00 [medline]
AID - 10.1002/ptr.5548 [doi]
PST - ppublish
SO  - Phytother Res. 2016 Mar;30(3):454-62. doi: 10.1002/ptr.5548. Epub 2015 Dec 21.