PMID- 26692934
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151222
LR  - 20201001
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 7
IP  - 10
DP  - 2015
TI  - Knockdown of EMMPRIN improves adverse remodeling mediated by IL-18 in the 
      post-infarcted heart.
PG  - 1908-16
AB  - Interleukin-18 (IL-18) exacerbates cardiac dysfunction following myocardial 
      infarction (MI). Extracellular matrix metalloproteinase inducer (EMMPRIN) has 
      been shown to exacerbate ventricular remodeling via induction of extracellular 
      matrix metalloproteinase (MMP) synthesis. While up-regulation of EMMPRIN 
      expression by IL-18 has been demonstrated in vitro, little is known regarding its 
      in vivo effects. Here, we investigated the role of EMMPRIN in progressive 
      post-infarct ventricular remodeling induced by IL-18. Cardiac function was 
      impaired on echocardiography and organ weight was increased in mice receiving 
      daily intraperitoneal injection of IL-18 following MI. Accompanying these adverse 
      functional effect were increased EMMPRIN levels. Gene silencing of cardiac 
      EMMPRIN by intramyocardial RNA interference rescued IL-18 mediated adverse 
      effects on post-infarct cardiac function. Finally, EMMPRIN silencing reduced 
      MMP-9 expression in the post-infarcted left ventricular myocardium. In 
      conclusion, progressive post-infarct left ventricular remodeling induced by IL-18 
      can be reversed by gene silencing of EMMPRIN. Knock down of EMMPRIN may be a 
      potential therapeutic strategy to abrogate the adverse effects of IL-18 on 
      post-infarct left ventricular remodeling likely via MMP-9 inhibition.
FAU - Su, Zizhuo
AU  - Su Z
AD  - Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University 
      Guangzhou, China ; Guangdong Province Key Laboratory of Arrhythmia and 
      Electrophysiology Guangzhou, China.
FAU - Lin, Rongjie
AU  - Lin R
AD  - Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University 
      Guangzhou, China ; Guangdong Province Key Laboratory of Arrhythmia and 
      Electrophysiology Guangzhou, China.
FAU - Chen, Yuyang
AU  - Chen Y
AD  - Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University 
      Guangzhou, China ; Guangdong Province Key Laboratory of Arrhythmia and 
      Electrophysiology Guangzhou, China.
FAU - Shu, Xiaorong
AU  - Shu X
AD  - Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University 
      Guangzhou, China ; Guangdong Province Key Laboratory of Arrhythmia and 
      Electrophysiology Guangzhou, China.
FAU - Zhang, Haifeng
AU  - Zhang H
AD  - Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University 
      Guangzhou, China ; Guangdong Province Key Laboratory of Arrhythmia and 
      Electrophysiology Guangzhou, China.
FAU - Nie, Ruqiong
AU  - Nie R
AD  - Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University 
      Guangzhou, China ; Guangdong Province Key Laboratory of Arrhythmia and 
      Electrophysiology Guangzhou, China.
FAU - Wang, Jingfeng
AU  - Wang J
AD  - Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University 
      Guangzhou, China ; Guangdong Province Key Laboratory of Arrhythmia and 
      Electrophysiology Guangzhou, China.
FAU - Xie, Shuanglun
AU  - Xie S
AD  - Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University 
      Guangzhou, China ; Guangdong Province Key Laboratory of Arrhythmia and 
      Electrophysiology Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20151015
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC4656767
OTO - NOTNLM
OT  - Interleukin-18
OT  - extracellular matrix metalloproteinase inducer
OT  - myocardial infarction
OT  - ventricular remodeling
EDAT- 2015/12/23 06:00
MHDA- 2015/12/23 06:01
PMCR- 2015/10/15
CRDT- 2015/12/23 06:00
PHST- 2015/07/28 00:00 [received]
PHST- 2015/09/28 00:00 [accepted]
PHST- 2015/12/23 06:00 [entrez]
PHST- 2015/12/23 06:00 [pubmed]
PHST- 2015/12/23 06:01 [medline]
PHST- 2015/10/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2015 Oct 15;7(10):1908-16. eCollection 2015.