PMID- 26693131
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151222
LR  - 20201001
IS  - 2194-7635 (Print)
IS  - 2194-7643 (Electronic)
IS  - 2194-7635 (Linking)
VI  - 4
IP  - 1
DP  - 2015 Dec
TI  - Late-Onset Aspergillus Fumigatus Infection of an Aortic Stent Graft in an 
      Immunocompetent Patient.
PG  - 56-8
LID - 10.1055/s-0035-1555013 [doi]
AB  - Aspergillus fumigatus as a clinical entity is difficult to diagnose. We present a 
      case, which could facilitate diagnosis and management of the aforementioned 
      disease. A 60-year-old man with stent graft implantation in the descending aorta 
      (6 years ago) presented with fever, night sweats, and weight loss over 5 months. 
      Leukocytosis and elevated C-reactive protein were constantly spiking. Blood 
      cultures were negative. Notably, the serum immunoglobulin E (IgE) level was 
      strongly elevated (> 1,000 U/mL). Anamnestically, the patient suffered from a 
      mild form of atopic dermatitis and bronchial asthma. The pulmonary status showed 
      no abnormalities in the computed tomography image. Nonetheless, a chest scan 
      revealed a suspected abscess around the stent graft of the descending aorta. 
      Extra-anatomic ascending to descending aortic bypass (Gelsoft 22 mm, Vascutek, 
      Juchinnan, Scotland, United Kingdom) was performed. Intraoperative samples 
      revealed A. fumigatus. These findings were confirmed by polymerase chain reaction 
      analysis. Infection by A. fumigatus represents a diagnostic challenge because 
      blood cultures are usually negative, but expeditious treatment is required to 
      prevent occurrence of irreversible complications. A late graft infection, 
      possibly caused by A. fumigatus should be suspected in patients with implanted 
      grafts, who suffer from unexplained, blood culture-negative fever that does not 
      respond to antibiotics and who have a history of dermatitis or bronchial asthma 
      with elevated IgE antibodies.
FAU - Ballazhi, Fatos
AU  - Ballazhi F
AD  - Department of Cardiac Surgery, Friedrich-Alexander University, 
      Erlangen-Nuremberg, Germany.
FAU - Weyand, Michael
AU  - Weyand M
AD  - Department of Cardiac Surgery, Friedrich-Alexander University, 
      Erlangen-Nuremberg, Germany.
FAU - Lang, Werner
AU  - Lang W
AD  - Department of Vascular Surgery, Friedrich-Alexander University, 
      Erlangen-Nuremberg, Germany.
FAU - Schoerner, Christoph
AU  - Schoerner C
AD  - Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich-Alexander 
      University Erlangen-Nuremberg, Erlangen, Germany.
FAU - Seitz, Timo
AU  - Seitz T
AD  - Department of Cardiac Surgery, Friedrich-Alexander University, 
      Erlangen-Nuremberg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20150710
PL  - United States
TA  - Thorac Cardiovasc Surg Rep
JT  - The Thoracic and cardiovascular surgeon reports
JID - 101629509
PMC - PMC4670309
OTO - NOTNLM
OT  - Aspergillus fumigatus
OT  - aorta
OT  - graft infection
EDAT- 2015/12/23 06:00
MHDA- 2015/12/23 06:01
PMCR- 2015/12/01
CRDT- 2015/12/23 06:00
PHST- 2015/01/12 00:00 [received]
PHST- 2015/04/28 00:00 [accepted]
PHST- 2015/12/23 06:00 [entrez]
PHST- 2015/12/23 06:00 [pubmed]
PHST- 2015/12/23 06:01 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 150150crv [pii]
AID - 10.1055/s-0035-1555013 [doi]
PST - ppublish
SO  - Thorac Cardiovasc Surg Rep. 2015 Dec;4(1):56-8. doi: 10.1055/s-0035-1555013. Epub 
      2015 Jul 10.