PMID- 26694163
OWN - NLM
STAT- MEDLINE
DCOM- 20160629
LR  - 20220409
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 12
DP  - 2015
TI  - Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR 
      in Laryngeal Carcinoma.
PG  - e0144924
LID - 10.1371/journal.pone.0144924 [doi]
LID - e0144924
AB  - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is the most common group 
      among head and neck cancers. LSCC is characterized by a high incidence in Europe. 
      With the aim of better understanding its genetic background we performed global 
      miRNA expression profiling of LSCC cell lines and primary specimens. By this 
      approach we identified a cohort of 33 upregulated and 9 downregulated miRNA genes 
      in LSCC as compared to epithelial no tumor controls. RESULTS: Within this group 
      we identified overexpression of the novel miR-1290 gene not reported in the 
      context of LSCC before. Using a combined bioinformatical approach in connection 
      with functional analysis we delineated two putative target genes of miR-1290 
      namely ITPR2 and MAF which are significantly downregulated in LSCC. They are 
      interesting candidates for tumor suppressor genes as they are implicated in 
      apoptosis and other processes deregulated in cancer. CONCLUSION: Taken together, 
      we propose miR-1290 as the new oncomiR involved in LSCC pathogenesis. 
      Additionally, we suggest that the oncogenic potential of miR-1290 might be 
      expressed by the involvement in downregulation of its target genes MAF and ITPR2.
FAU - Janiszewska, Joanna
AU  - Janiszewska J
AD  - Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer 
      Genetics, Poznan, Poland.
FAU - Szaumkessel, Marcin
AU  - Szaumkessel M
AD  - Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer 
      Genetics, Poznan, Poland.
FAU - Kostrzewska-Poczekaj, Magdalena
AU  - Kostrzewska-Poczekaj M
AD  - Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer 
      Genetics, Poznan, Poland.
FAU - Bednarek, Kinga
AU  - Bednarek K
AD  - Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer 
      Genetics, Poznan, Poland.
FAU - Paczkowska, Julia
AU  - Paczkowska J
AD  - Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer 
      Genetics, Poznan, Poland.
FAU - Jackowska, Joanna
AU  - Jackowska J
AD  - Department of Otolaryngology and Laryngological Oncology, University of Medical 
      Sciences, Poznan, Poland.
FAU - Grenman, Reidar
AU  - Grenman R
AD  - Department of Otorhinolaryngology, Head and Neck Surgery and Department of 
      Medical Biochemistry, Turku University Hospital and University of Turku, Turku, 
      Finland.
FAU - Szyfter, Krzysztof
AU  - Szyfter K
AD  - Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer 
      Genetics, Poznan, Poland.
AD  - Department of Audiology and Phoniatry, University of Medical Sciences, Poznan, 
      Poland.
FAU - Wierzbicka, Malgorzata
AU  - Wierzbicka M
AD  - Department of Otolaryngology and Laryngological Oncology, University of Medical 
      Sciences, Poznan, Poland.
FAU - Giefing, Maciej
AU  - Giefing M
AD  - Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer 
      Genetics, Poznan, Poland.
AD  - Department of Otolaryngology and Laryngological Oncology, University of Medical 
      Sciences, Poznan, Poland.
FAU - Jarmuz-Szymczak, Malgorzata
AU  - Jarmuz-Szymczak M
AD  - Institute of Human Genetics, Polish Academy of Sciences, Department of Cancer 
      Genetics, Poznan, Poland.
AD  - Department of Hematology, K. Marcinkowski University of Medical Sciences, Poznan, 
      Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151222
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (3' Untranslated Regions)
RN  - 0 (ITPR2 protein, human)
RN  - 0 (Inositol 1,4,5-Trisphosphate Receptors)
RN  - 0 (MAF protein, human)
RN  - 0 (MIRN1290 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Proto-Oncogene Proteins c-maf)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Cell Line, Tumor
MH  - Computational Biology/methods
MH  - Female
MH  - Gene Expression Profiling/*methods
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Inositol 1,4,5-Trisphosphate Receptors/*genetics
MH  - Laryngeal Neoplasms/*genetics
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Oligonucleotide Array Sequence Analysis/methods
MH  - Proto-Oncogene Proteins c-maf/*genetics
PMC - PMC4692263
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/12/24 06:00
MHDA- 2016/06/30 06:00
PMCR- 2015/12/22
CRDT- 2015/12/24 06:00
PHST- 2015/04/20 00:00 [received]
PHST- 2015/10/21 00:00 [accepted]
PHST- 2015/12/24 06:00 [entrez]
PHST- 2015/12/24 06:00 [pubmed]
PHST- 2016/06/30 06:00 [medline]
PHST- 2015/12/22 00:00 [pmc-release]
AID - PONE-D-15-17002 [pii]
AID - 10.1371/journal.pone.0144924 [doi]
PST - epublish
SO  - PLoS One. 2015 Dec 22;10(12):e0144924. doi: 10.1371/journal.pone.0144924. 
      eCollection 2015.