PMID- 26696365
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20171023
IS  - 1749-4486 (Electronic)
IS  - 1749-4478 (Linking)
VI  - 41
IP  - 6
DP  - 2016 Dec
TI  - Effect of postoperative proton pump inhibitor therapy on voice outcomes following 
      phonomicrosurgery for vocal fold polyp: a randomized controlled study.
PG  - 730-736
LID - 10.1111/coa.12611 [doi]
AB  - OBJECTIVE: To determine the effect of a postoperative proton pump inhibitor (PPI) 
      on voice outcomes after phonomicrosurgery in patients with vocal fold polyp. 
      STUDY DESIGN: This is a prospective, randomized controlled study. SETTINGS: This 
      study was carried out in a tertiary care referral medical centre. PARTICIPANTS: A 
      total of 48 patients underwent phonomicrosurgery for vocal fold polyps. After 
      surgery, patients were randomized to the PPI group (lansoprazole 15 mg twice 
      daily for 2 months) and the non-PPI group. MAIN OUTCOME MEASURES: Voice handicap 
      index (VHI) and perceptual and acoustic voice analysis were evaluated at baseline 
      and 2 months after surgery. RESULTS: Among 48 enrolled patients, a total of 42 
      patients [non-PPI group (n = 23), PPI group (n = 19)] completed the study. The 
      VHI, perceptual and most acoustic parameters significantly improved in both 
      groups after surgery. However, there was no significant difference in the per 
      cent of change in those parameters. CONCLUSION: Postoperative PPI treatment did 
      not significantly influence voice outcomes after phonomicrosurgery in patients 
      with vocal fold polyp.
CI  - (c) 2015 John Wiley & Sons Ltd.
FAU - Lee, Y C
AU  - Lee YC
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Korea.
FAU - Na, S Y
AU  - Na SY
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Korea.
FAU - Kim, H J
AU  - Kim HJ
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Korea.
FAU - Yang, C W
AU  - Yang CW
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Korea.
FAU - Kim, S I
AU  - Kim SI
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Korea.
FAU - Byun, Y S
AU  - Byun YS
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Korea.
FAU - Jung, A R
AU  - Jung AR
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Korea.
FAU - Ryu, I Y
AU  - Ryu IY
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Korea.
FAU - Eun, Y G
AU  - Eun YG
AD  - Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Kyung Hee 
      University, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160219
PL  - England
TA  - Clin Otolaryngol
JT  - Clinical otolaryngology : official journal of ENT-UK ; official journal of 
      Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
JID - 101247023
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Lansoprazole/therapeutic use
MH  - Laryngeal Diseases/*surgery
MH  - Laryngoscopy
MH  - Male
MH  - *Microsurgery
MH  - Middle Aged
MH  - Polyps/*surgery
MH  - Postoperative Care
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Treatment Outcome
MH  - *Vocal Cords
MH  - *Voice Quality/drug effects
EDAT- 2015/12/24 06:00
MHDA- 2017/10/24 06:00
CRDT- 2015/12/24 06:00
PHST- 2015/12/13 00:00 [accepted]
PHST- 2015/12/24 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2015/12/24 06:00 [entrez]
AID - 10.1111/coa.12611 [doi]
PST - ppublish
SO  - Clin Otolaryngol. 2016 Dec;41(6):730-736. doi: 10.1111/coa.12611. Epub 2016 Feb 
      19.