PMID- 26696854
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151223
LR  - 20240324
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 9
DP  - 2015
TI  - Exploring Female Mice Interstrain Differences Relevant for Models of Depression.
PG  - 335
LID - 10.3389/fnbeh.2015.00335 [doi]
LID - 335
AB  - Depression is an extremely heterogeneous disorder. Diverse molecular mechanisms 
      have been suggested to underlie its etiology. To understand the molecular 
      mechanisms responsible for this complex disorder, researchers have been using 
      animal models extensively, namely mice from various genetic backgrounds and 
      harboring distinct genetic modifications. The use of numerous mouse models has 
      contributed to enrich our knowledge on depression. However, accumulating data 
      also revealed that the intrinsic characteristics of each mouse strain might 
      influence the experimental outcomes, which may justify some conflicting evidence 
      reported in the literature. To further understand the impact of the genetic 
      background, we performed a multimodal comparative study encompassing the most 
      relevant parameters commonly addressed in depression, in three of the most widely 
      used mouse strains: Balb/c, C57BL/6, and CD-1. Moreover, female mice were 
      selected for this study taken into account the higher prevalence of depression in 
      women and the fewer animal studies using this gender. Our results show that 
      Balb/c mice have a more pronounced anxious-like behavior than CD-1 and C57BL/6 
      mice, whereas C57BL/6 animals present the strongest depressive-like trait. 
      Furthermore, C57BL/6 mice display the highest rate of proliferating cells and 
      brain-derived neurotrophic factor (Bdnf) expression levels in the hippocampus, 
      while hippocampal dentate granular neurons of Balb/c mice show smaller dendritic 
      lengths and fewer ramifications. Of notice, the expression levels of inducible 
      nitric oxide synthase (iNos) predict 39.5% of the depressive-like behavior index, 
      which suggests a key role of hippocampal iNOS in depression. Overall, this study 
      reveals important interstrain differences in several behavioral dimensions and 
      molecular and cellular parameters that should be considered when preparing and 
      analyzing experiments addressing depression using mouse models. It further 
      contributes to the literature by revealing the predictive value of hippocampal 
      iNos expression levels in depressive-like behavior, irrespectively of the mouse 
      strain.
FAU - de Sa-Calcada, Daniela
AU  - de Sa-Calcada D
AD  - Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 
      University of Minho Braga, Portugal ; ICVS/3B's Research Group - PT Government 
      Associate Laboratory Braga, Portugal.
FAU - Roque, Susana
AU  - Roque S
AD  - Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 
      University of Minho Braga, Portugal ; ICVS/3B's Research Group - PT Government 
      Associate Laboratory Braga, Portugal.
FAU - Branco, Carlos
AU  - Branco C
AD  - Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 
      University of Minho Braga, Portugal ; ICVS/3B's Research Group - PT Government 
      Associate Laboratory Braga, Portugal.
FAU - Monteiro, Susana
AU  - Monteiro S
AD  - Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 
      University of Minho Braga, Portugal ; ICVS/3B's Research Group - PT Government 
      Associate Laboratory Braga, Portugal.
FAU - Cerqueira-Rodrigues, Bruno
AU  - Cerqueira-Rodrigues B
AD  - Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 
      University of Minho Braga, Portugal ; ICVS/3B's Research Group - PT Government 
      Associate Laboratory Braga, Portugal.
FAU - Sousa, Nuno
AU  - Sousa N
AD  - Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 
      University of Minho Braga, Portugal ; ICVS/3B's Research Group - PT Government 
      Associate Laboratory Braga, Portugal.
FAU - Palha, Joana A
AU  - Palha JA
AD  - Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 
      University of Minho Braga, Portugal ; ICVS/3B's Research Group - PT Government 
      Associate Laboratory Braga, Portugal.
FAU - Correia-Neves, Margarida
AU  - Correia-Neves M
AD  - Life and Health Sciences Research Institute (ICVS), School of Health Sciences, 
      University of Minho Braga, Portugal ; ICVS/3B's Research Group - PT Government 
      Associate Laboratory Braga, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20151210
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC4674561
OTO - NOTNLM
OT  - anxious-like behavior
OT  - cytokines
OT  - dentate gyrus neurons' morphology
OT  - depressive-like behavior
OT  - females
OT  - hippocampal cell proliferation
OT  - mouse strains
EDAT- 2015/12/24 06:00
MHDA- 2015/12/24 06:01
PMCR- 2015/01/01
CRDT- 2015/12/24 06:00
PHST- 2015/08/11 00:00 [received]
PHST- 2015/11/19 00:00 [accepted]
PHST- 2015/12/24 06:00 [entrez]
PHST- 2015/12/24 06:00 [pubmed]
PHST- 2015/12/24 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2015.00335 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2015 Dec 10;9:335. doi: 10.3389/fnbeh.2015.00335. 
      eCollection 2015.