PMID- 26697500
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20220410
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis.
PG  - 6194750
LID - 10.1155/2016/6194750 [doi]
LID - 6194750
AB  - OBJECTIVE: To investigate the association between circulating betatrophin level 
      and type 2 diabetes mellitus (T2DM) in human. METHODS: A comprehensive literature 
      search was performed in PubMed and Embase databases to identify eligible studies 
      assessing the circulating levels of betatrophin in both T2DM patients and 
      nondiabetic adults. RESULTS: A total of nine eligible studies with twelve 
      comparisons were included for the final meta-analysis. Circulating betatrophin 
      levels in T2DM patients were higher than those in the nondiabetic controls 
      (random-effect SMD 0.53; 95% CI 0.13 to 0.94; P = 0.010). In the subgroup of 
      nonobese population but not the obese population, the overall betatrophin level 
      in T2DM patients was much higher than that in the nondiabetic controls (nonobese: 
      random-effect SMD, 0.82; 95% CI 0.42 to 1.21; P < 0.001; obese: random-effect 
      SMD, -0.39; 95% CI, -0.95 to 0.18; P = 0.18). Metaregression indicated that body 
      mass index of T2DM patients was associated with mean difference of betatrophin 
      level between T2DM and nondiabetic adults (slope, -578.8; t = -2.7; P = 0.02). 
      CONCLUSION: Based on the findings of our meta-analysis, circulating betatrophin 
      level of T2DM patients is higher than that of nondiabetic adults in the nonobese 
      population, but not in the obese population.
FAU - Li, Sheyu
AU  - Li S
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu, Sichuan 610041, China.
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu, Sichuan 610041, China.
FAU - Li, Ling
AU  - Li L
AD  - Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China.
FAU - Li, Yun
AU  - Li Y
AD  - Department of Endocrinology and Metabolism, The Third People's Hospital of 
      Chengdu, Chengdu, Sichuan 610031, China.
FAU - Li, Qianrui
AU  - Li Q
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu, Sichuan 610041, China.
FAU - An, Zhenmei
AU  - An Z
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu, Sichuan 610041, China.
FAU - Sun, Xin
AU  - Sun X
AD  - Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, China.
FAU - Tian, Haoming
AU  - Tian H
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, No. 37 Guoxue Road, Chengdu, Sichuan 610041, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20151201
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (ANGPTL8 protein, human)
RN  - 0 (Angiopoietin-Like Protein 8)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Peptide Hormones)
SB  - IM
MH  - Angiopoietin-Like Protein 8
MH  - Angiopoietin-like Proteins
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Humans
MH  - Insulin Resistance
MH  - Obesity/*blood/complications
MH  - Peptide Hormones/*blood
PMC - PMC4678092
EDAT- 2015/12/24 06:00
MHDA- 2016/10/07 06:00
PMCR- 2015/12/01
CRDT- 2015/12/24 06:00
PHST- 2015/04/16 00:00 [received]
PHST- 2015/06/12 00:00 [revised]
PHST- 2015/06/15 00:00 [accepted]
PHST- 2015/12/24 06:00 [entrez]
PHST- 2015/12/24 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 10.1155/2016/6194750 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:6194750. doi: 10.1155/2016/6194750. Epub 2015 Dec 1.