PMID- 26699560
OWN - NLM
STAT- MEDLINE
DCOM- 20160928
LR  - 20181113
IS  - 1526-9914 (Electronic)
IS  - 1526-9914 (Linking)
VI  - 16
IP  - 6
DP  - 2015 Nov 8
TI  - Dose differences in intensity-modulated radiotherapy plans calculated with pencil 
      beam and Monte Carlo for lung SBRT.
PG  - 91-99
LID - 10.1120/jacmp.v16i6.5514 [doi]
AB  - For patients with medically inoperable early-stage non-small cell lung cancer 
      (NSCLC) treated with stereotactic body radiation therapy, early treatment plans 
      were based on a simpler dose calculation algorithm, the pencil beam (PB) 
      calculation. Because these patients had the longest treatment follow-up, 
      identifying dose differences between the PB calculated dose and Monte Carlo 
      calculated dose is clinically important for understanding of treatment outcomes. 
      Previous studies found significant dose differences between the PB dose 
      calculation and more accurate dose calculation algorithms, such as 
      convolution-based or Monte Carlo (MC), mostly for three-dimensional conformal 
      radiotherapy (3D CRT) plans. The aim of this study is to investigate whether 
      these observed dose differences also exist for intensity-modulated radiotherapy 
      (IMRT) plans for both centrally and peripherally located tumors. Seventy patients 
      (35 central and 35 peripheral) were retrospectively selected for this study. The 
      clinical IMRT plans that were initially calculated with the PB algorithm were 
      recalculated with the MC algorithm. Among these paired plans, dosimetric 
      parameters were compared for the targets and critical organs. When compared to MC 
      calculation, PB calculation overestimated doses to the planning target volumes 
      (PTVs) of central and peripheral tumors with different magnitudes. The doses to 
      95% of the central and peripheral PTVs were overestimated by 9.7% +/- 5.6% and 
      12.0% +/- 7.3%, respectively. This dose overestimation did not affect doses to the 
      critical organs, such as the spinal cord and lung. In conclusion, for NSCLC 
      treated with IMRT, dose differences between the PB and MC calculations were 
      different from that of 3D CRT. No significant dose differences in critical organs 
      were observed between the two calculations.
FAU - Liu, Han
AU  - Liu H
AD  - Cleveland Clinic. 123@123.com.
FAU - Zhuang, Tingliang
AU  - Zhuang T
FAU - Stephans, Kevin
AU  - Stephans K
FAU - Videtic, Gregory
AU  - Videtic G
FAU - Raithel, Stephen
AU  - Raithel S
FAU - Djemil, Toufik
AU  - Djemil T
FAU - Xia, Ping
AU  - Xia P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151108
PL  - United States
TA  - J Appl Clin Med Phys
JT  - Journal of applied clinical medical physics
JID - 101089176
SB  - IM
MH  - Algorithms
MH  - Carcinoma, Non-Small-Cell Lung/*radiotherapy/*surgery
MH  - Humans
MH  - Lung Neoplasms/*radiotherapy/*surgery
MH  - Monte Carlo Method
MH  - Organs at Risk
MH  - Radiosurgery/*methods/statistics & numerical data
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods/statistics & numerical data
MH  - Radiotherapy, Intensity-Modulated/*methods/statistics & numerical data
MH  - Retrospective Studies
PMC - PMC5690987
EDAT- 2015/12/25 06:00
MHDA- 2016/09/30 06:00
PMCR- 2015/11/08
CRDT- 2015/12/25 06:00
PHST- 2014/12/17 00:00 [received]
PHST- 2015/08/07 00:00 [accepted]
PHST- 2015/09/21 00:00 [revised]
PHST- 2015/12/25 06:00 [entrez]
PHST- 2015/12/25 06:00 [pubmed]
PHST- 2016/09/30 06:00 [medline]
PHST- 2015/11/08 00:00 [pmc-release]
AID - ACM20091 [pii]
AID - 10.1120/jacmp.v16i6.5514 [doi]
PST - epublish
SO  - J Appl Clin Med Phys. 2015 Nov 8;16(6):91-99. doi: 10.1120/jacmp.v16i6.5514.