PMID- 26699724
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20190221
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 47
IP  - 3
DP  - 2016 Mar
TI  - Small cell lung cancer in never-smokers.
PG  - 947-53
LID - 10.1183/13993003.01524-2015 [doi]
AB  - Our aim was to describe the characteristics of a case-series of never-smoker 
      small cell lung cancer (SCLC) cases.Cases of SCLC were selected from a 
      prospective, multicenter, hospital-based case-control study performed in Spain. 
      Participants were never-smokers older than 30 years with an anatomo-pathological 
      confirmation of primary lung cancer. We collected clinical and epidemiological 
      variables according to the study's protocol.We included 19 SCLC cases, 18 females 
      (94.7%), median age 75 years (interquartile range (IQR) 70-80 years). Median 
      residential radon concentration was 195 Bq.m(-3) (IQR 130-229 Bq.m(-3)). 10 
      patients had limited disease and nine had extended disease. Median survival was 
      242 days (IQR 94-496 days); 1- and 2-year survival were 36.8% and 17.6%, 
      respectively. Survival was much higher for individuals with limited disease than 
      for those with extended disease (median 336 versus 235 days; 1-year survival 50% 
      versus 22.2% and 2-year survival 27% versus 0%, respectively). Performance status 
      at diagnosis was closely related to survival.SCLC is an infrequent, highly 
      aggressive disease in never-smokers. Survival is poor, even for limited disease. 
      Age at diagnosis in SCLC is higher than that observed for never-smokers with 
      adenocarcinoma. Residential radon exposure is higher than the action levels 
      recommended by the World Health Organization.
CI  - Copyright (c)ERS 2016.
FAU - Torres-Duran, Maria
AU  - Torres-Duran M
AD  - Service of Pneumology, University Hospital Complex of Vigo, Vigo, Spain.
FAU - Ruano-Ravina, Alberto
AU  - Ruano-Ravina A
AD  - Dept of Preventive Medicine and Public Health, University of Santiago de 
      Compostela, Santiago de Compostela, Spain CIBER de Epidemiologia y Salud Publica 
      (CIBERESP), Spain Dept of Epidemiology, Brown School of Public Health, Brown 
      University, Providence, Rhode Island, USA alberto.ruano@usc.es.
FAU - Kelsey, Karl T
AU  - Kelsey KT
AD  - Dept of Epidemiology, Brown School of Public Health, Brown University, 
      Providence, Rhode Island, USA.
FAU - Parente-Lamelas, Isaura
AU  - Parente-Lamelas I
AD  - Service of Pneumology, Ourense Hospital Complex, Ourense, Spain.
FAU - Provencio, Mariano
AU  - Provencio M
AD  - Service of Oncology, Puerta de Hierro University Hospital, Madrid, Spain.
FAU - Leiro-Fernandez, Virginia
AU  - Leiro-Fernandez V
AD  - Service of Pneumology, University Hospital Complex of Vigo, Vigo, Spain.
FAU - Abal-Arca, Jose
AU  - Abal-Arca J
AD  - Service of Pneumology, Ourense Hospital Complex, Ourense, Spain.
FAU - Montero-Martinez, Carmen
AU  - Montero-Martinez C
AD  - Service of Pneumology, University Hospital Complex of A Coruna, A Coruna, Spain.
FAU - Vidal-Garcia, Iria
AU  - Vidal-Garcia I
AD  - Service of Pneumology, University Hospital Complex of A Coruna, A Coruna, Spain.
FAU - Pena, Carolina
AU  - Pena C
AD  - Service of Oncology, Oncologic Center of A Coruna, A Coruna, Spain.
FAU - Castro-Anon, Olalla
AU  - Castro-Anon O
AD  - Service of Pneumology, Hospital Lucus Augusti, Lugo, Spain.
FAU - Golpe-Gomez, Antonio
AU  - Golpe-Gomez A
AD  - Service of Pneumology, Santiago de Compostela University Clinic Hospital, 
      Santiago de Compostela, Spain.
FAU - Martinez, Cristina
AU  - Martinez C
AD  - National Institute of Silicosis, University Hospital of Asturias, Oviedo, Spain.
FAU - Guzman-Taveras, Rosirys
AU  - Guzman-Taveras R
AD  - National Institute of Silicosis, University Hospital of Asturias, Oviedo, Spain.
FAU - Mejuto-Marti, Maria Jose
AU  - Mejuto-Marti MJ
AD  - Service of Pneumology, Arquitecto Marcide Hospital, Ferrol, Spain.
FAU - Fernandez-Villar, Alberto
AU  - Fernandez-Villar A
AD  - Service of Pneumology, University Hospital Complex of Vigo, Vigo, Spain.
FAU - Barros-Dios, Juan Miguel
AU  - Barros-Dios JM
AD  - Dept of Preventive Medicine and Public Health, University of Santiago de 
      Compostela, Santiago de Compostela, Spain CIBER de Epidemiologia y Salud Publica 
      (CIBERESP), Spain Service of Preventive Medicine, University Hospital Complex of 
      Santiago de Compostela, Santiago de Compostela, Spain.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20151223
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - Q74S4N8N1G (Radon)
SB  - IM
MH  - Adenocarcinoma/diagnosis/*epidemiology
MH  - Adenocarcinoma of Lung
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Housing
MH  - Humans
MH  - Lung Neoplasms/diagnosis/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radon/*adverse effects
MH  - Risk Factors
MH  - Small Cell Lung Carcinoma/diagnosis/*epidemiology
MH  - Smoking
MH  - Spain
EDAT- 2015/12/25 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/12/25 06:00
PHST- 2015/09/11 00:00 [received]
PHST- 2015/11/12 00:00 [accepted]
PHST- 2015/12/25 06:00 [entrez]
PHST- 2015/12/25 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 13993003.01524-2015 [pii]
AID - 10.1183/13993003.01524-2015 [doi]
PST - ppublish
SO  - Eur Respir J. 2016 Mar;47(3):947-53. doi: 10.1183/13993003.01524-2015. Epub 2015 
      Dec 23.