PMID- 26700098
OWN - NLM
STAT- MEDLINE
DCOM- 20161024
LR  - 20211203
IS  - 1873-3735 (Electronic)
IS  - 0165-6147 (Print)
IS  - 0165-6147 (Linking)
VI  - 37
IP  - 4
DP  - 2016 Apr
TI  - Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
PG  - 303-317
LID - S0165-6147(15)00247-3 [pii]
LID - 10.1016/j.tips.2015.11.011 [doi]
AB  - The increasing epidemic of obesity and its comorbidities has spurred research 
      interest in adipose biology and its regulatory functions. Recent studies have 
      revealed that the mechanistic target of rapamycin (mTOR) signaling pathway has a 
      critical role in the regulation of adipose tissue function, including 
      adipogenesis, lipid metabolism, thermogenesis, and adipokine synthesis and/or 
      secretion. Given the importance of mTOR signaling in controlling energy 
      homeostasis, it is not unexpected that deregulated mTOR signaling is associated 
      with obesity and related metabolic disorders. In this review, we highlight 
      current advances in understanding the roles of the mTOR signaling pathway in 
      adipose tissue. We also provide a more nuanced view of how the mTOR signaling 
      pathway regulates adipose tissue biology and function. Finally, we describe 
      approaches to modulate the activity and tissue-specific function of mTOR that may 
      pave the way towards counteracting obesity and related metabolic diseases.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Cai, Huan
AU  - Cai H
AD  - Institute of Metabolism and Endocrinology, Metabolic Syndrome Research Center, 
      the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, 
      China; Department of Pharmacology, UTHSCSA, San Antonio, TX, USA.
FAU - Dong, Lily Q
AU  - Dong LQ
AD  - Departments of Cellular Structural Biology, UTHSCSA, San Antonio, TX, USA.
FAU - Liu, Feng
AU  - Liu F
AD  - Institute of Metabolism and Endocrinology, Metabolic Syndrome Research Center, 
      the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, 
      China; Department of Pharmacology, UTHSCSA, San Antonio, TX, USA. Electronic 
      address: LiuF@uthscsa.edu.
LA  - eng
GR  - R01 DK080344/DK/NIDDK NIH HHS/United States
GR  - R01 DK100697/DK/NIDDK NIH HHS/United States
GR  - DK100697/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151214
PL  - England
TA  - Trends Pharmacol Sci
JT  - Trends in pharmacological sciences
JID - 7906158
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adipose Tissue/drug effects/*metabolism
MH  - Animals
MH  - Humans
MH  - Lipogenesis/drug effects
MH  - Lipolysis/drug effects
MH  - Molecular Targeted Therapy
MH  - Obesity/drug therapy/metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/antagonists & inhibitors/*metabolism
PMC - PMC4811695
MID - NIHMS746297
OTO - NOTNLM
OT  - adipogenesis
OT  - adipokine
OT  - lipid metabolism
OT  - the mechanistic target of rapamycin (mTOR)
OT  - thermogenesis
EDAT- 2015/12/25 06:00
MHDA- 2016/10/25 06:00
PMCR- 2017/04/01
CRDT- 2015/12/25 06:00
PHST- 2015/10/12 00:00 [received]
PHST- 2015/11/19 00:00 [revised]
PHST- 2015/11/20 00:00 [accepted]
PHST- 2015/12/25 06:00 [entrez]
PHST- 2015/12/25 06:00 [pubmed]
PHST- 2016/10/25 06:00 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - S0165-6147(15)00247-3 [pii]
AID - 10.1016/j.tips.2015.11.011 [doi]
PST - ppublish
SO  - Trends Pharmacol Sci. 2016 Apr;37(4):303-317. doi: 10.1016/j.tips.2015.11.011. 
      Epub 2015 Dec 14.