PMID- 26702768
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1532-8430 (Electronic)
IS  - 0022-0736 (Linking)
VI  - 49
IP  - 2
DP  - 2016 Mar-Apr
TI  - Diagnostic accuracy of a novel method for detection of acute transmural 
      myocardial ischemia based upon a self-applicable 3-lead configuration.
PG  - 192-201
LID - S0022-0736(15)00375-1 [pii]
LID - 10.1016/j.jelectrocard.2015.11.007 [doi]
AB  - BACKGROUND: Delayed medical attendance is a leading cause of death in patients 
      with ST elevation myocardial infarction (STEMI). METHODS: We aimed to introduce, 
      develop, and validate a novel method (RELF method) for detection of transmural 
      ischemia based on a new and easy-to-use 3-lead configuration and 
      orthonormalization of ST reference vectors (STDVN). The study included 60 
      patients undergoing coronary artery occlusion (CAO) during balloon inflation and 
      30 healthy subjects. RESULTS: STDVN was significantly different and an optimal 
      discriminator between CAO patients and healthy subjects (respectively 8.00+/-4.50 
      vs. 1.90+/-0.86 normalized units, p<0.001). Compared to the 12-lead ECG, the RELF 
      method was sensitive (90 vs. 73%, p=0.13) and more specific (91 vs. 75%, 
      p<0.001). CONCLUSIONS: The RELF method is highly accurate for early detection of 
      acute occlusion related ischemia and it outperforms the conventional 12-lead ECG 
      criteria for STEMI. This method provides a platform for self-detection of CAO 
      with handheld devices or smart phones.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - El Haddad, Milad
AU  - El Haddad M
AD  - Department of Cardiology, Heart Center, Ghent University Hospital, Ghent, 
      Belgium.
FAU - Vervloet, Delphine
AU  - Vervloet D
AD  - Department of Cardiology, Heart Center, Ghent University Hospital, Ghent, 
      Belgium.
FAU - Taeymans, Yves
AU  - Taeymans Y
AD  - Department of Cardiology, Heart Center, Ghent University Hospital, Ghent, 
      Belgium.
FAU - De Buyzere, Marc
AU  - De Buyzere M
AD  - Department of Cardiology, Heart Center, Ghent University Hospital, Ghent, 
      Belgium.
FAU - Bove, Thierry
AU  - Bove T
AD  - Department of Cardiology, Heart Center, Ghent University Hospital, Ghent, 
      Belgium.
FAU - Stroobandt, Roland
AU  - Stroobandt R
AD  - Department of Cardiology, Heart Center, Ghent University Hospital, Ghent, 
      Belgium.
FAU - Duytschaever, Mattias
AU  - Duytschaever M
AD  - Department of Cardiology, Heart Center, Ghent University Hospital, Ghent, 
      Belgium.
FAU - Malmivuo, Jaakko
AU  - Malmivuo J
AD  - Department of Electrical Engineering and Automation, Aalto University, Espoo, 
      Finland.
FAU - Gheeraert, Peter
AU  - Gheeraert P
AD  - Department of Cardiology, Heart Center, Ghent University Hospital, Ghent, 
      Belgium. Electronic address: peter.gheeraert@ugent.be.
LA  - eng
PT  - Journal Article
DEP - 20151123
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - Adult
MH  - Aged
MH  - Algorithms
MH  - Coronary Stenosis/complications/*diagnosis
MH  - Diagnosis, Computer-Assisted/instrumentation/*methods
MH  - Electrocardiography/instrumentation/*methods
MH  - Electrodes
MH  - Female
MH  - Humans
MH  - Male
MH  - Mobile Applications
MH  - Myocardial Ischemia/*diagnosis/etiology
MH  - Reproducibility of Results
MH  - Self Care/instrumentation/*methods
MH  - Sensitivity and Specificity
MH  - Telemedicine/instrumentation/*methods
OTO - NOTNLM
OT  - Diagnosis
OT  - Electrocardiography
OT  - Heart arrest
OT  - Myocardial infarction
EDAT- 2015/12/26 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/12/26 06:00
PHST- 2015/08/25 00:00 [received]
PHST- 2015/12/26 06:00 [entrez]
PHST- 2015/12/26 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0022-0736(15)00375-1 [pii]
AID - 10.1016/j.jelectrocard.2015.11.007 [doi]
PST - ppublish
SO  - J Electrocardiol. 2016 Mar-Apr;49(2):192-201. doi: 
      10.1016/j.jelectrocard.2015.11.007. Epub 2015 Nov 23.