PMID- 26703652 OWN - NLM STAT- MEDLINE DCOM- 20160809 LR - 20191210 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 13 IP - 1 DP - 2015 Dec 22 TI - Statistical Validation of a Web-Based GIS Application and Its Applicability to Cardiovascular-Related Studies. PG - ijerph13010002 LID - 10.3390/ijerph13010002 [doi] LID - 2 AB - PURPOSE: There is abundant evidence that neighborhood characteristics are significantly linked to the health of the inhabitants of a given space within a given time frame. This study is to statistically validate a web-based GIS application designed to support cardiovascular-related research developed by the NIH funded Research Centers in Minority Institutions (RCMI) Translational Research Network (RTRN) Data Coordinating Center (DCC) and discuss its applicability to cardiovascular studies. METHODS: Geo-referencing, geocoding and geospatial analyses were conducted for 500 randomly selected home addresses in a U.S. southeastern Metropolitan area. The correlation coefficient, factor analysis and Cronbach's alpha (alpha) were estimated to quantify measures of the internal consistency, reliability and construct/criterion/discriminant validity of the cardiovascular-related geospatial variables (walk score, number of hospitals, fast food restaurants, parks and sidewalks). RESULTS: Cronbach's alpha for CVD GEOSPATIAL variables was 95.5%, implying successful internal consistency. Walk scores were significantly correlated with number of hospitals (r = 0.715; p < 0.0001), fast food restaurants (r = 0.729; p < 0.0001), parks (r = 0.773; p < 0.0001) and sidewalks (r = 0.648; p < 0.0001) within a mile from homes. It was also significantly associated with diversity index (r = 0.138, p = 0.0023), median household incomes (r = -0.181; p < 0.0001), and owner occupied rates (r = -0.440; p < 0.0001). However, its non-significant correlation was found with median age, vulnerability, unemployment rate, labor force, and population growth rate. CONCLUSION: Our data demonstrates that geospatial data generated by the web-based application were internally consistent and demonstrated satisfactory validity. Therefore, the GIS application may be useful to apply to cardiovascular-related studies aimed to investigate potential impact of geospatial factors on diseases and/or the long-term effect of clinical trials. FAU - Lee, Jae Eun AU - Lee JE AD - Research Centers in Minority Institutions Translational Research Network Data Coordinating Center, 1230 Raymond Road, Jackson, MS 39204, USA. jae.e.lee@jsums.edu. AD - Department of Epidemiology and Biostatistics, School of Public Health, Jackson State University, 350 W. Woodrow Wilson Drive Jackson Medical Mall, Suite 301, Jackson, MS 39213, USA. jae.e.lee@jsums.edu. FAU - Sung, Jung Hye AU - Sung JH AD - Research Centers in Minority Institutions Translational Research Network Data Coordinating Center, 1230 Raymond Road, Jackson, MS 39204, USA. Jung.h.lee@jsums.edu. AD - Department of Epidemiology and Biostatistics, School of Public Health, Jackson State University, 350 W. Woodrow Wilson Drive Jackson Medical Mall, Suite 301, Jackson, MS 39213, USA. Jung.h.lee@jsums.edu. FAU - Malouhi, Mohamad AU - Malouhi M AD - Research Centers in Minority Institutions Translational Research Network Data Coordinating Center, 1230 Raymond Road, Jackson, MS 39204, USA. mohamad.malouhi@rtrn.net. LA - eng GR - U54 MD008149/MD/NIMHD NIH HHS/United States GR - U54MD008149/MD/NIMHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20151222 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Adult MH - Aged MH - Cardiovascular Diseases/*prevention & control MH - Cities/*statistics & numerical data MH - Data Interpretation, Statistical MH - Environment Design MH - Factor Analysis, Statistical MH - Fast Foods/*statistics & numerical data MH - Female MH - *Geographic Information Systems MH - Hospitals/*statistics & numerical data MH - Humans MH - Internet MH - Male MH - Middle Aged MH - Parks, Recreational/*statistics & numerical data MH - Reproducibility of Results MH - Residence Characteristics MH - Southeastern United States MH - Walking/*statistics & numerical data MH - Young Adult PMC - PMC4730393 OTO - NOTNLM OT - Statistical validation OT - accessibility to healthcare facilities OT - density of fast-food restaurant OT - social determinants of cardiovascular disease OT - walkability OT - web-based GIS application EDAT- 2015/12/26 06:00 MHDA- 2016/08/10 06:00 PMCR- 2016/01/01 CRDT- 2015/12/26 06:00 PHST- 2015/07/13 00:00 [received] PHST- 2015/09/30 00:00 [revised] PHST- 2015/10/14 00:00 [accepted] PHST- 2015/12/26 06:00 [entrez] PHST- 2015/12/26 06:00 [pubmed] PHST- 2016/08/10 06:00 [medline] PHST- 2016/01/01 00:00 [pmc-release] AID - ijerph13010002 [pii] AID - ijerph-13-00002 [pii] AID - 10.3390/ijerph13010002 [doi] PST - epublish SO - Int J Environ Res Public Health. 2015 Dec 22;13(1):ijerph13010002. doi: 10.3390/ijerph13010002.