PMID- 26703678
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20181202
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 13
IP  - 1
DP  - 2015 Dec 22
TI  - Computer Optimization of Biodegradable Nanoparticles Fabricated by Dispersion 
      Polymerization.
PG  - ijerph13010047
LID - 10.3390/ijerph13010047 [doi]
LID - 47
AB  - Quality by design (QbD) in the pharmaceutical industry involves designing and 
      developing drug formulations and manufacturing processes which ensure predefined 
      drug product specifications. QbD helps to understand how process and formulation 
      variables affect product characteristics and subsequent optimization of these 
      variables vis-a-vis final specifications. Statistical design of experiments (DoE) 
      identifies important parameters in a pharmaceutical dosage form design followed 
      by optimizing the parameters with respect to certain specifications. DoE 
      establishes in mathematical form the relationships between critical process 
      parameters together with critical material attributes and critical quality 
      attributes. We focused on the fabrication of biodegradable nanoparticles by 
      dispersion polymerization. Aided by a statistical software, d-optimal mixture 
      design was used to vary the components (crosslinker, initiator, stabilizer, and 
      macromonomers) to obtain twenty nanoparticle formulations (PLLA-based 
      nanoparticles) and thirty formulations (poly-varepsilon-caprolactone-based nanoparticles). 
      Scheffe polynomial models were generated to predict particle size (nm), zeta 
      potential, and yield (%) as functions of the composition of the formulations. 
      Simultaneous optimizations were carried out on the response variables. Solutions 
      were returned from simultaneous optimization of the response variables for 
      component combinations to (1) minimize nanoparticle size; (2) maximize the 
      surface negative zeta potential; and (3) maximize percent yield to make the 
      nanoparticle fabrication an economic proposition.
FAU - Akala, Emmanuel O
AU  - Akala EO
AD  - Center for Drug Research and Development, Department of Pharmaceutical Sciences, 
      College of Pharmacy, Howard University, 2300 4th Street NW, Washington, DC 20059, 
      USA. eakala@howard.edu.
FAU - Adesina, Simeon
AU  - Adesina S
AD  - Center for Drug Research and Development, Department of Pharmaceutical Sciences, 
      College of Pharmacy, Howard University, 2300 4th Street NW, Washington, DC 20059, 
      USA. simeon.adesina@howard.edu.
FAU - Ogunwuyi, Oluwaseun
AU  - Ogunwuyi O
AD  - Center for Drug Research and Development, Department of Pharmaceutical Sciences, 
      College of Pharmacy, Howard University, 2300 4th Street NW, Washington, DC 20059, 
      USA. temytayoo@yahoo.com.
LA  - eng
GR  - 1SC1CA199810-01/CA/NCI NIH HHS/United States
GR  - C06 RR020608/RR/NCRR NIH HHS/United States
GR  - 5P30A1087714-02/PHS HHS/United States
GR  - 1 C06 RR 020608-01/RR/NCRR NIH HHS/United States
GR  - C06 RR014469/RR/NCRR NIH HHS/United States
GR  - 1 C06 RR 14469-01/RR/NCRR NIH HHS/United States
GR  - SC1 CA199810/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151222
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Chemistry, Pharmaceutical
MH  - *Computer-Aided Design
MH  - Drug Industry/*methods
MH  - Nanoparticles/*chemistry
MH  - Particle Size
MH  - *Polymerization
MH  - Technology, Pharmaceutical/*methods
PMC - PMC4730438
OTO - NOTNLM
OT  - ">d-optimal mixture design
OT  - computer optimization
OT  - dispersion polymerization
OT  - nanoparticles
OT  - quality by design (QbD)
OT  - statistical design of experiments
EDAT- 2015/12/26 06:00
MHDA- 2016/09/13 06:00
PMCR- 2016/01/01
CRDT- 2015/12/26 06:00
PHST- 2015/08/15 00:00 [received]
PHST- 2015/11/04 00:00 [revised]
PHST- 2015/11/12 00:00 [accepted]
PHST- 2015/12/26 06:00 [entrez]
PHST- 2015/12/26 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - ijerph13010047 [pii]
AID - ijerph-13-00047 [pii]
AID - 10.3390/ijerph13010047 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2015 Dec 22;13(1):ijerph13010047. doi: 
      10.3390/ijerph13010047.