PMID- 26704143
OWN - NLM
STAT- MEDLINE
DCOM- 20160526
LR  - 20181202
IS  - 1538-9235 (Electronic)
IS  - 1040-5488 (Linking)
VI  - 93
IP  - 2
DP  - 2016 Feb
TI  - Macular Diagnostic Ability in OCT for Assessing Glaucoma in High Myopia.
PG  - 126-35
LID - 10.1097/OPX.0000000000000776 [doi]
AB  - PURPOSE: To compare the diagnostic abilities of spectral-domain optical coherence 
      tomography (SD-OCT; Spectralis OCT) and time-domain OCT (TD-OCT; Stratus OCT). 
      Changes in macular parameters in highly myopic eyes of glaucoma patients and 
      highly myopic eyes of glaucoma suspects were evaluated and compared. METHODS: We 
      collected data from 72 highly myopic eyes (spherical equivalent, </=-6.0D). 
      Forty-one eyes had perimetric glaucoma and 31 eyes were suspected to have 
      glaucoma (control group). All eyes underwent SD-OCT and TD-OCT imaging. Area 
      under the receiver operating characteristic (AUROC) curve and sensitivity were 
      examined on macular volume and thickness parameters at a fixed specificity and 
      compared between groups. RESULTS: The highest TD-OCT AUROC curves were found 
      using outer inferior sector macular thickness (AUROC curve, 0.911) and volume 
      (AUROC curve, 0.909). The highest SD-OCT AUROC curves were found using outer 
      inferior region thickness (AUROC curve, 0.836) and volume (AUROC curve, 0.834). 
      The difference between the two imaging modalities was not statistically 
      significant (thickness, p = 0.141; volume, p = 0.138). The sensitivity of TD-OCT 
      macular outer inferior average thickness was highest and was 88.2%, with a 
      specificity of 80.4%. The sensitivity of TD-OCT average volume measurements in 
      this same region was 76.5%, with a specificity of 91.3%. The SD-OCT average 
      thickness measurements also had the highest sensitivity in this region, which was 
      78.6%, with a specificity of 82.1%. The SD-OCT volume measurements had a 
      sensitivity of 67.9%, with a specificity of 92.3%. CONCLUSIONS: Both SD-OCT and 
      TD-OCT measurements of outer inferior macular thickness and volume can 
      differentiate between eyes of glaucoma patients and glaucoma suspects with high 
      myopia. These independent predictors all had good sensitivity. Based on our 
      results, SD-OCT and TD-OCT have similar diagnostic abilities. These parameters 
      may provide useful additional data in highly myopic eyes to complement standard 
      glaucoma diagnosis tools.
FAU - Hung, Kuo-Chi
AU  - Hung KC
AD  - *MD daggerMD, PhD double daggerPhD Department of Ophthalmology, Kaohsiung Chang Gung Memorial 
      Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (K-CH, 
      P-CW, Y-CP, H-WC, I-CL, J-CT, P-WL, and M-CT); and Department of Biological 
      Sciences, National Sun Yat-Sen University, Taiwan (H-WC).
FAU - Wu, Pei-Chang
AU  - Wu PC
FAU - Poon, Yi-Chieh
AU  - Poon YC
FAU - Chang, Hsueh-Wen
AU  - Chang HW
FAU - Lai, Ing-Chou
AU  - Lai IC
FAU - Tsai, Jen-Chia
AU  - Tsai JC
FAU - Lin, Pei-Wen
AU  - Lin PW
FAU - Teng, Mei-Ching
AU  - Teng MC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Optom Vis Sci
JT  - Optometry and vision science : official publication of the American Academy of 
      Optometry
JID - 8904931
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Gonioscopy
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Middle Aged
MH  - Myopia, Degenerative/*complications
MH  - Ocular Hypertension/diagnosis
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/instrumentation/*methods
MH  - Visual Field Tests
EDAT- 2015/12/26 06:00
MHDA- 2016/05/27 06:00
CRDT- 2015/12/26 06:00
PHST- 2015/12/26 06:00 [entrez]
PHST- 2015/12/26 06:00 [pubmed]
PHST- 2016/05/27 06:00 [medline]
AID - 10.1097/OPX.0000000000000776 [doi]
PST - ppublish
SO  - Optom Vis Sci. 2016 Feb;93(2):126-35. doi: 10.1097/OPX.0000000000000776.