PMID- 26704826
OWN - NLM
STAT- MEDLINE
DCOM- 20170213
LR  - 20181202
IS  - 1744-5116 (Electronic)
IS  - 1388-0209 (Linking)
VI  - 54
IP  - 9
DP  - 2016 Sep
TI  - Protective effects of fenofibrate and resveratrol in an aggressive model of 
      rheumatoid arthritis in rats.
PG  - 1705-15
LID - 10.3109/13880209.2015.1125931 [doi]
AB  - Context Fibrates were reported to have anti-inflammatory effects while the 
      naturally occurring polyphenol resveratrol was traditionally known as a potent 
      antioxidant agent. Objective The effects of fenofibrate and resveratrol were 
      investigated on complete Freund's adjuvant (CFA)-induced rheumatoid arthritis 
      (RA) in adult female albino rats. Materials and methods Rats were divided into a 
      normal control group, an arthritis control group receiving CFA, two reference 
      treatment groups receiving dexamesathone (1.5 mg/kg/day) and methotrexate 
      (1 mg/kg/day), and two treatment groups receiving fenofibrate (100 mg/kg/day) and 
      resveratrol (10 mg/kg/day) for seven consecutive days. Assessment of RA was 
      performed by measuring serum rheumatoid factor (RF), matrix metalloprotinease-3 
      (MMP-3) and cartilage oligomeric matrix protein (COMP) as specific rheumatoid 
      biomarkers, immunoglobulin G (IgG) and antinuclear antibody (ANA) as 
      immunological biomarkers, tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 
      (IL-10) as immunomodulatory cytokines, myeloperoxidase (MPO) and C-reactive 
      protein (CRP) as inflammatory biomarkers and malondialdehyde (MDA) and 
      glutathione (GSH) as oxidative stress biomarkers, supported by a 
      histopathological study on joints and spleens. Results Serum RF, MMP-3, COMP, 
      IgG, ANA, TNF-alpha, MPO, CRP and MDA were decreased to about 36, 56, 66, 65, 9, 35, 
      24, 44 and 31% by fenofibrate, and to about 37, 59, 44, 70, 5, 30, 23, 33 and 28% 
      by resveratrol treatments, respectively. Alternatively, serum IL-10 and GSH were 
      significantly increased to about 215 and 251% by fenofibrate and to about 225 and 
      273% by resveratrol treatments, respectively. Discussion and conclusion 
      Fenofibrate and resveratrol protect against RA, possibly through their 
      immunomodulatory, anti-inflammatory and antioxidant potential.
FAU - Wahba, Mariam G F
AU  - Wahba MG
AD  - a Department of Pharmacology and Toxicology , Faculty of Pharmacy, Nahda 
      University , Beni-Sueif , Egypt ;
FAU - Messiha, Basim A S
AU  - Messiha BA
AD  - b Department of Pharmacology and Toxicology , Faculty of Pharmacy, Beni-Suef 
      University , Beni-Sueif , Egypt.
FAU - Abo-Saif, Ali A
AU  - Abo-Saif AA
AD  - b Department of Pharmacology and Toxicology , Faculty of Pharmacy, Beni-Suef 
      University , Beni-Sueif , Egypt.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20151224
PL  - England
TA  - Pharm Biol
JT  - Pharmaceutical biology
JID - 9812552
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Stilbenes)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9007-81-2 (Freund's Adjuvant)
RN  - Q369O8926L (Resveratrol)
RN  - U202363UOS (Fenofibrate)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/isolation & purification/*pharmacology
MH  - Antioxidants/isolation & purification/*pharmacology
MH  - Antirheumatic Agents/isolation & purification/*pharmacology
MH  - Arthritis, Experimental/blood/chemically induced/immunology/*prevention & control
MH  - Biomarkers/blood
MH  - Cytokines/blood
MH  - Dexamethasone/pharmacology
MH  - Female
MH  - Fenofibrate/*pharmacology
MH  - Freund's Adjuvant
MH  - Immunosuppressive Agents/isolation & purification/*pharmacology
MH  - Inflammation Mediators/blood
MH  - Joints/drug effects/metabolism/pathology
MH  - Methotrexate/pharmacology
MH  - Oxidative Stress/drug effects
MH  - Rats, Wistar
MH  - Resveratrol
MH  - Spleen/drug effects/metabolism/pathology
MH  - Stilbenes/*pharmacology
OTO - NOTNLM
OT  - Anti-inflammatory
OT  - antioxidant
OT  - complete Freund's adjuvant
OT  - dexamethasone
OT  - immuno-modulatory
OT  - methotrexate
EDAT- 2015/12/26 06:00
MHDA- 2017/02/14 06:00
CRDT- 2015/12/26 06:00
PHST- 2015/12/26 06:00 [entrez]
PHST- 2015/12/26 06:00 [pubmed]
PHST- 2017/02/14 06:00 [medline]
AID - 10.3109/13880209.2015.1125931 [doi]
PST - ppublish
SO  - Pharm Biol. 2016 Sep;54(9):1705-15. doi: 10.3109/13880209.2015.1125931. Epub 2015 
      Dec 24.