PMID- 26705487
OWN - NLM
STAT- MEDLINE
DCOM- 20171012
LR  - 20220321
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Print)
IS  - 2047-2404 (Linking)
VI  - 17
IP  - 10
DP  - 2016 Oct
TI  - Creation of mortality risk charts using 123I meta-iodobenzylguanidine 
      heart-to-mediastinum ratio in patients with heart failure: 2- and 5-year risk 
      models.
PG  - 1138-45
LID - 10.1093/ehjci/jev322 [doi]
AB  - AIMS: (123)I meta-iodobenzylguanidine (MIBG) imaging has been extensively used 
      for prognostication in patients with chronic heart failure (CHF). The purpose of 
      this study was to create mortality risk charts for short-term (2 years) and 
      long-term (5 years) prediction of cardiac mortality. METHODS AND RESULTS: Using a 
      pooled database of 1322 CHF patients, multivariate analysis, including 
      (123)I-MIBG late heart-to-mediastinum ratio (HMR), left ventricular ejection 
      fraction (LVEF), and clinical factors, was performed to determine optimal 
      variables for the prediction of 2- and 5-year mortality risk using subsets of the 
      patients (n = 1280 and 933, respectively). Multivariate logistic regression 
      analysis was performed to create risk charts. Cardiac mortality was 10 and 22% 
      for the sub-population of 2- and 5-year analyses. A four-parameter multivariate 
      logistic regression model including age, New York Heart Association (NYHA) 
      functional class, LVEF, and HMR was used. Annualized mortality rate was <1% in 
      patients with NYHA Class I-II and HMR >/= 2.0, irrespective of age and LVEF. In 
      patients with NYHA Class III-IV, mortality rate was 4-6 times higher for HMR < 
      1.40 compared with HMR >/= 2.0 in all LVEF classes. Among the subset of patients 
      with b-type natriuretic peptide (BNP) results (n = 491 and 359 for 2- and 5-year 
      models, respectively), the 5-year model showed incremental value of HMR in 
      addition to BNP. CONCLUSION: Both 2- and 5-year risk prediction models with 
      (123)I-MIBG HMR can be used to identify low-risk as well as high-risk patients, 
      which can be effective for further risk stratification of CHF patients even when 
      BNP is available.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of the European 
      Society of Cardiology.
FAU - Nakajima, Kenichi
AU  - Nakajima K
AD  - Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, 
      Kanazawa 920-8641, Japan nakajima@med.kanazawa-u.ac.jp.
FAU - Nakata, Tomoaki
AU  - Nakata T
AD  - Hakodate Goryoukaku Hospital, Hakodate-City, Japan.
FAU - Matsuo, Shinro
AU  - Matsuo S
AD  - Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, 
      Kanazawa 920-8641, Japan.
FAU - Jacobson, Arnold F
AU  - Jacobson AF
AD  - Diagram Consulting, Kihei, HI, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20151224
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
MH  - *3-Iodobenzylguanidine
MH  - Aged
MH  - *Cause of Death
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Databases, Factual
MH  - Female
MH  - Heart Failure/*diagnostic imaging/*mortality
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Positron-Emission Tomography/*methods
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Survival Analysis
MH  - Time Factors
PMC - PMC5031228
OTO - NOTNLM
OT  - 123I meta-iodobenzylguanidine
OT  - cardiac death
OT  - chronic heart failure
OT  - prediction model
OT  - prognosis
OT  - risk chart
EDAT- 2015/12/26 06:00
MHDA- 2017/10/13 06:00
PMCR- 2015/12/24
CRDT- 2015/12/26 06:00
PHST- 2015/10/01 00:00 [received]
PHST- 2014/11/13 00:00 [accepted]
PHST- 2015/12/26 06:00 [entrez]
PHST- 2015/12/26 06:00 [pubmed]
PHST- 2017/10/13 06:00 [medline]
PHST- 2015/12/24 00:00 [pmc-release]
AID - jev322 [pii]
AID - 10.1093/ehjci/jev322 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2016 Oct;17(10):1138-45. doi: 
      10.1093/ehjci/jev322. Epub 2015 Dec 24.