PMID- 26705881
OWN - NLM
STAT- MEDLINE
DCOM- 20160519
LR  - 20160118
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 117
IP  - 3
DP  - 2016 Feb 1
TI  - Usefulness of Electrocardiographic Voltage to Determine Myocardial Fibrosis in 
      Hypertrophic Cardiomyopathy.
PG  - 443-9
LID - S0002-9149(15)02253-5 [pii]
LID - 10.1016/j.amjcard.2015.11.015 [doi]
AB  - Classic electrocardiographic (ECG) voltage indexes have been applied to screen 
      for left ventricular (LV) hypertrophy in hypertrophic cardiomyopathy (HC). 
      However, it is unclear whether low ECG voltage reflects deteriorated electrical 
      forces because of replacement of the myocardium by fibrotic tissues in HC. We 
      investigated correlations between classic ECG voltage indexes (Cornell, total QRS 
      voltage, and Sokolow-Lyon) and cardiac magnetic resonance (CMR) parameters 
      focusing on the impact of low ECG voltage on the LV ejection fraction (LVEF) and 
      myocardial fibrosis in HC. We studied 108 consecutive patients with HC who 
      underwent CMR imaging with late gadolinium enhancement (LGE). Nineteen patients 
      with complete right or left bundle branch block were excluded, leaving 89 
      patients for analysis (age 61.0 +/- 13.9 years; 58 men). Of the 3 voltage indexes, 
      the total QRS voltage and Sokolow-Lyon indexes were positively correlated with 
      LVEF. For discriminating patients with end-stage HC (LVEF <50%) from patients 
      with HC and preserved LVEF (>/= 50%), receiver-operating characteristic analysis 
      revealed an excellent area under the curve of 0.87 for the total QRS voltage 
      index and 0.90 for the Sokolow-Lyon index, whereas the area under the curve for 
      the Cornell index was only 0.54 (p <0.01). Moreover, these 2 voltage indexes were 
      negatively correlated with the extent of LGE-determined myocardial fibrosis when 
      adjusted by the LV maximal wall thickness. In conclusion, low ECG voltage indexes 
      may reflect increased myocardial fibrosis in patients with HC.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Konno, Tetsuo
AU  - Konno T
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan; Research and Education Center for Innovative and 
      Preventive Medicine, Kanazawa University, Kanazawa, Japan. Electronic address: 
      konnokontetsu@staff.kanazawa-u.ac.jp.
FAU - Nagata, Yoji
AU  - Nagata Y
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Teramoto, Ryota
AU  - Teramoto R
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Fujino, Noboru
AU  - Fujino N
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Nomura, Akihiro
AU  - Nomura A
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Tada, Hayato
AU  - Tada H
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Sakata, Kenji
AU  - Sakata K
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Furusho, Hiroshi
AU  - Furusho H
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Takamura, Masayuki
AU  - Takamura M
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Nakamura, Hiroyuki
AU  - Nakamura H
AD  - Research and Education Center for Innovative and Preventive Medicine, Kanazawa 
      University, Kanazawa, Japan; Department of Public Health, Graduate School of 
      Medical Science, Kanazawa University, Kanazawa, Japan.
FAU - Kawashiri, Masa-Aki
AU  - Kawashiri MA
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Yamagishi, Masakazu
AU  - Yamagishi M
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
FAU - Hayashi, Kenshi
AU  - Hayashi K
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kanazawa 
      University, Kanazawa, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151119
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
CIN - Am J Cardiol. 2017 Aug 1;120(3):e27. PMID: 27553107
MH  - Cardiomyopathy, Hypertrophic/diagnosis/etiology/*physiopathology
MH  - Disease Progression
MH  - *Electrocardiography
MH  - Female
MH  - Fibrosis/complications/diagnosis
MH  - Heart Ventricles/*pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - ROC Curve
MH  - Severity of Illness Index
MH  - Stroke Volume/*physiology
MH  - Ventricular Function, Left/*physiology
EDAT- 2015/12/27 06:00
MHDA- 2016/05/20 06:00
CRDT- 2015/12/27 06:00
PHST- 2015/09/10 00:00 [received]
PHST- 2015/11/03 00:00 [revised]
PHST- 2015/11/03 00:00 [accepted]
PHST- 2015/12/27 06:00 [entrez]
PHST- 2015/12/27 06:00 [pubmed]
PHST- 2016/05/20 06:00 [medline]
AID - S0002-9149(15)02253-5 [pii]
AID - 10.1016/j.amjcard.2015.11.015 [doi]
PST - ppublish
SO  - Am J Cardiol. 2016 Feb 1;117(3):443-9. doi: 10.1016/j.amjcard.2015.11.015. Epub 
      2015 Nov 19.