PMID- 26707180
OWN - NLM
STAT- MEDLINE
DCOM- 20161027
LR  - 20220310
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 13
IP  - 2
DP  - 2016 Feb
TI  - Nano-microcapsule basic fibroblast growth factor combined with hypoxia-inducible 
      factor-1 improves random skin flap survival in rats.
PG  - 1661-6
LID - 10.3892/mmr.2015.4699 [doi]
AB  - The present study aimed to investigate the effect of nano-microcapsule-basic 
      fibroblast growth factor (bFGF) combined with hypoxia-inducible factor-1 (HIF-1) 
      on the random skin flap survival of rats. Male Sprague-Dawley rats were used to 
      establish the McFarlane flap model and subsequently, all model rats were randomly 
      divided into four groups: Control, bFGF, HIF-1 and bFGF combined with HIF-1. The 
      model rats were treated with 2.5 microg/day bFGF and 1.0 microg/day HIF-1 for 5 days by 
      intraperitoneal injection. On day 5 following treatment, the boundaries between 
      necrotic and surviving regions were significantly inhibited by bFGF combined with 
      HIF-1. bFGF combined with HIF-1 inhibited oxidative stresses and inflammatory 
      factors in random skin flap survival of rats. bFGF combined with HIF-1 also 
      activated the protein expression levels of cyclooxygenase (COX)-2 and vascular 
      endothelial growth factor (VEGF) in the random skin flap survival of rats. In 
      conclusion, nano-microcapsule bFGF combined with HIF-1 prevented random skin flap 
      survival in rats through antioxidative, anti-inflammatory and activation of the 
      protein expression levels of COX-2 and VEGF.
FAU - Chen, Guang-Jun
AU  - Chen GJ
AD  - Department of Hand and Plastic Surgery, The 2nd Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, Zhejiang 325027, P.R. China.
FAU - Chen, Yi-Heng
AU  - Chen YH
AD  - Department of Hand and Plastic Surgery, The 2nd Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, Zhejiang 325027, P.R. China.
FAU - Yang, Xia-Qing
AU  - Yang XQ
AD  - Department of Hand and Plastic Surgery, The 2nd Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, Zhejiang 325027, P.R. China.
FAU - Li, Zhi-Jie
AU  - Li ZJ
AD  - Department of Hand and Plastic Surgery, The 2nd Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, Zhejiang 325027, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151221
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Capsules)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (vascular endothelial growth factor A, rat)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (Ptgs2 protein, rat)
SB  - IM
MH  - Animals
MH  - Capsules/*administration & dosage
MH  - Cyclooxygenase 2/biosynthesis
MH  - Fibroblast Growth Factor 2/*administration & dosage/chemistry
MH  - Gene Expression Regulation
MH  - Graft Survival
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*administration & dosage/chemistry
MH  - Male
MH  - Nanoparticles/administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin Abnormalities/*drug therapy/pathology
MH  - Surgical Flaps/pathology
MH  - Vascular Endothelial Growth Factor A/biosynthesis
EDAT- 2015/12/29 06:00
MHDA- 2016/11/01 06:00
CRDT- 2015/12/29 06:00
PHST- 2015/03/22 00:00 [received]
PHST- 2015/10/29 00:00 [accepted]
PHST- 2015/12/29 06:00 [entrez]
PHST- 2015/12/29 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - 10.3892/mmr.2015.4699 [doi]
PST - ppublish
SO  - Mol Med Rep. 2016 Feb;13(2):1661-6. doi: 10.3892/mmr.2015.4699. Epub 2015 Dec 21.