PMID- 26708886
OWN - NLM
STAT- MEDLINE
DCOM- 20160504
LR  - 20221207
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 23
IP  - 6
DP  - 2015 Dec
TI  - [Establishment of Primary Adult MDS Nested Case-Control Study Cohort and Study of 
      Risk Factors Associated with MDS Evolution to Leukemia].
PG  - 1638-46
LID - 10.7534/j.issn.1009-2137.2015.06.021 [doi]
AB  - OBJECTIVE: To establish a nested case-control study cohort in myelodysplastic 
      syndrome (MDS) patients and investigate the clinical characteristics, WHO subtype 
      and risk factors associated with MDS evolution to leukemia of this cohort. 
      METHODS: All patients, >/=18 years of age, provided by 24 Shanghai hospitals with 
      initial clinical findings consistent with a hematopoietic abnormality between 
      June 2003 and April 2007, were the candidates for inclusion in this study. The 
      blood and bone marrow samples of every patient should be provided at baseline. 
      Diagnosis was made by incorporating morphologic, immunophenotypic, cytogenetic 
      and molecular features according to WHO classification criteria. Cytogenetic 
      analysis was performed using conventional G-banding karyotyping and fluorescence 
      in situ hybridization (FISH) techniques. Cumulative risk of evolution was 
      estimated by Kaplan-Meier method. Prognostic factors were evaluated by univariate 
      Log-rank method and multivariate Cox proportional hazard models. RESULTS: A total 
      of 435 patients were diagnosed as MDS. The median age of MDS onset was 58(18-90) 
      years, with 248 male patients and 187 female patients (male: female 1.33: 1). The 
      percentage of cases with refractory cytopenia with multilineage dysplasia (RCMD) 
      was the highest (65.5%), while that of refraetory anemia (RA) (2.3%), refractory 
      anenia with ring sideroblast (RARS) (1.1%) and 5q-syndrome (0.5%) was lower. 
      Trisomy 8 (+8) was the most common chromosome abnormalities (71 cases, 12.7%). 
      The mean follow-up time was 20.3 (4.2-57.1) months. Cases were patients with 
      evolution by the end of follow-up, while controls were patients without evolution 
      by that time. Case group included 41 patients and control group included 342 
      patients. Univariate analysis showed that the age, sex, WHO subtype, WBC count, 
      absolute neutrophil count (ANC), IPSS cytogenetic subgroup, IPSS group and bone 
      marrow blast percentage were significant risk factors for leukemia-free survival 
      (LFS). Multivariate analysis of COX model showed that the age, sex, WHO subtype, 
      IPSS cytogenetic subgroup and bone marrow blast were independent risk factors for 
      LFS. CONCLUSION: A nested case-control study cohort of MDS patients is 
      established. The clinical characteristics and WHO subtype of MDS patients in 
      Chinese Shanghai are different from that in Western countries. The independent 
      risk factors for MDS evolution are age, sex, WHO subtype, IPSS cytogenetic 
      subgroup and bone marrow blast percentage.
FAU - Ma, Yan
AU  - Ma Y
AD  - Department of Hematology, Huashan Hospital, Fudan Universtiy, Shanghai, 200040, 
      China.
FAU - Chen, Bo-Bin
AU  - Chen BB
AD  - Department of Hematology, Huashan Hospital, Fudan Universtiy, Shanghai, 200040, 
      China.
FAU - Wang, Xiao-Qin
AU  - Wang XQ
AD  - Department of Hematology, Huashan Hospital, Fudan Universtiy, Shanghai, 200040, 
      China.
FAU - Xu, Xiao-Ping
AU  - Xu XP
AD  - Department of Hematology, Huashan Hospital, Fudan Universtiy, Shanghai, 200040, 
      China. E-mail: xpxu1111@163.com.
FAU - Lin, Guo-Wei
AU  - Lin GW
AD  - Department of Hematology, Huashan Hospital, Fudan Universtiy, Shanghai, 200040, 
      China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - Chromosome 5, trisomy 5q
RN  - Chromosome 8, trisomy
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Bone Marrow
MH  - Case-Control Studies
MH  - China
MH  - Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 5
MH  - Chromosomes, Human, Pair 8
MH  - Cri-du-Chat Syndrome
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - *Leukemia
MH  - Male
MH  - Middle Aged
MH  - *Myelodysplastic Syndromes
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Trisomy
MH  - Young Adult
EDAT- 2015/12/29 06:00
MHDA- 2016/05/05 06:00
CRDT- 2015/12/29 06:00
PHST- 2015/12/29 06:00 [entrez]
PHST- 2015/12/29 06:00 [pubmed]
PHST- 2016/05/05 06:00 [medline]
AID - 1009-2137(2015)06-1638-09 [pii]
AID - 10.7534/j.issn.1009-2137.2015.06.021 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Dec;23(6):1638-46. doi: 
      10.7534/j.issn.1009-2137.2015.06.021.