PMID- 26709222
OWN - NLM
STAT- MEDLINE
DCOM- 20170421
LR  - 20170421
IS  - 2410-8650 (Electronic)
IS  - 1607-551X (Linking)
VI  - 31
IP  - 12
DP  - 2015 Dec
TI  - Association of HLA and cytokine gene polymorphisms with idiopathic pulmonary 
      fibrosis.
PG  - 613-20
LID - S1607-551X(15)00236-3 [pii]
LID - 10.1016/j.kjms.2015.10.007 [doi]
AB  - Idiopathic pulmonary fibrosis (IPF) is a rare, progressive, and lethal 
      interstitial lung disease with unknown etiology. Divergent observations have 
      suggested that genetic factors contribute to IPF susceptibility. This study 
      investigated the relationship between human leukocyte antigen (HLA), cytokine 
      gene polymorphisms, and IPF in a Chinese Han population. The gene polymorphisms 
      of HLA-A, -B, -DRB1, tumor necrosis factor alpha [TNF-alpha (-308 A/G)], transforming 
      growth factor beta [TGF-beta1 (+869 T/C)], interleukin 10 [IL-10 (-592 C/A, -819 
      T/C, and -1082 G/A)], and interferon gamma [IFN-gamma (+874 T/A)] were detected in 
      102 individuals with IPF and 266 unrelated normal controls using PCR with 
      sequence-specific primers and a high-resolution melt (HRM) approach. The data 
      showed that there was no difference in HLA allele frequencies between the IPF and 
      control groups. However, the data showed the frequency of HLA-A*02-DRB1*04 
      haplotype in the IPF group was significantly higher than that in the control 
      group [odds ratio (OR) = 4.69, 95% confidence interval (CI) = 1.82-12.08, 
      p < 0.001]. In addition, no differences in the allele and genotype distributions 
      of the cytokines were found between the IPF and control groups (p > 0.01). Our 
      findings suggest that there is an association between specific HLA haplotype and 
      IPF genetic susceptibility and that the genetic variability of some cytokines may 
      not be involved in the pathogenesis of IPF.
CI  - Copyright (c) 2015. Published by Elsevier Taiwan.
FAU - Zhang, Hai-Ping
AU  - Zhang HP
AD  - Department of Derma Science Laboratory, Wuxi Number 2 People's Hospital 
      Affiliated with Nanjing Medical University, Wuxi, Jiangsu Province, PR China.
FAU - Zou, Jian
AU  - Zou J
AD  - Department of Clinical Laboratory Science, Wuxi People's Hospital Affiliated with 
      Nanjing Medical University, Wuxi, Jiangsu Province, PR China; Jiangsu Key 
      Laboratory of Organ Transplantation, Wuxi, Jiangsu Province, PR China.
FAU - Xie, Ping
AU  - Xie P
AD  - Department of Clinical Laboratory Science, Wuxi People's Hospital Affiliated with 
      Nanjing Medical University, Wuxi, Jiangsu Province, PR China; Jiangsu Key 
      Laboratory of Organ Transplantation, Wuxi, Jiangsu Province, PR China.
FAU - Gao, Fei
AU  - Gao F
AD  - Department of Thoracic Surgery, Wuxi People's Hospital Affiliated with Nanjing 
      Medical University, Wuxi, Jiangsu Province, PR China.
FAU - Mu, Hui-Jun
AU  - Mu HJ
AD  - Department of Clinical Laboratory Science, Wuxi People's Hospital Affiliated with 
      Nanjing Medical University, Wuxi, Jiangsu Province, PR China; Jiangsu Key 
      Laboratory of Organ Transplantation, Wuxi, Jiangsu Province, PR China. Electronic 
      address: wxmuhj@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20151130
PL  - China (Republic : 1949- )
TA  - Kaohsiung J Med Sci
JT  - The Kaohsiung journal of medical sciences
JID - 100960562
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Cytokines/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/*genetics/*immunology
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
OTO - NOTNLM
OT  - Cytokine
OT  - Gene polymorphism
OT  - Human leukocyte antigen
OT  - Idiopathic pulmonary fibrosis
EDAT- 2015/12/29 06:00
MHDA- 2017/04/22 06:00
CRDT- 2015/12/29 06:00
PHST- 2015/04/28 00:00 [received]
PHST- 2015/10/19 00:00 [revised]
PHST- 2015/10/05 00:00 [accepted]
PHST- 2015/12/29 06:00 [entrez]
PHST- 2015/12/29 06:00 [pubmed]
PHST- 2017/04/22 06:00 [medline]
AID - S1607-551X(15)00236-3 [pii]
AID - 10.1016/j.kjms.2015.10.007 [doi]
PST - ppublish
SO  - Kaohsiung J Med Sci. 2015 Dec;31(12):613-20. doi: 10.1016/j.kjms.2015.10.007. 
      Epub 2015 Nov 30.